Ultrastructural changes occurred prior to
massive proteinuria, including diffuse podocyte foot process effacement, swelling of the mitochondria, and disarrangement of microfilaments.
One month after the acute period, she had elevated BUN and serum creatinine levels and
massive proteinuria.
A slow increase of proteinuria and the absence of hypoalbuminemia and edema even in the presence of
massive proteinuria are very characteristic of hyperfiltering FSGS.
Chronic kidney disease is characterized by reduced glomerular filtration and persistent
massive proteinuria. Because of its increasing morbidity and mortality, chronic kidney disease has become an important research field [1].
All the patients had edema and
massive proteinuria, 97% hypoalbuminemia, 94% hypercholesterolemia and 54% oliguria.
