massive perivillous fibrin deposition

massive perivillous fibrin deposition

A placental lesion associated with intrauterine growth restriction and stillbirth, characterised by fibrin deposition over >80% of the placental surface. Recurrence may be rare in second- and ­­third-trimester placentas, but relatively common in first-trimester spontaneous abortions.
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Furthermore, other cases reported that the application of Pra could restore the balance of angiogenesis and prevent recurrent fetal death in massive perivillous fibrin deposition of the placenta.[6] A previous study on the mechanism of Pra in animal models addressed the regulation of the angiogenic factors, improvement of vascular endothelial cell function, reduction of oxidative stress, and the regulation of the immune system.[7]
Pravastatin to prevent recurrent fetal death in massive perivillous fibrin deposition of the placenta (MPFD).
Chronic histiocytic intervillositis has been suggested to be along the spectrum of the more recognized lesion known as villitis of unknown etiology, (5) along with massive perivillous fibrin deposition and maternal floor infarction.
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