Global Market Outline: Q-TOF Mass Spectrometry
The parameters of ten kinds of metabolites detected by ion trap mass spectrometry
Metabolites parent ion CE ion Citric acid 191 87 25eV D-Frutose-6-phosphate dipotassium salt 259 97 27eV Dipotassium D-Glucose-6-phosphate 259 97078.9 27eV 2-ketoglutaric acid 145 101 18eV Glutamic acid 146 128 20eV Fumaric acid 115 71 20eV Pyruvic acid 87 87 10eV Aspartic acid 132 88 27eV Succitric acid 117 73 27eV Isocitric acid trisodium salt hydrate 191 1110173.1 27eV Table 3.
"This information can serve as complementary when treating patients," Wong, the co-director of the Clinical and Translational Mass Spectrometry
Center, told Laboratory Equipment.
If externally validated IA is used, assay and method details should be communicated to the clinician with the assay result ADT: androgen-deprivation therapy; IA: immunoassay; LC-MS/MS: liquid chromatography tandem mass spectrometry
; MS: mass spectrometry
Similar to PSI, aluminum-foil mass spectrometry
(Al-ESI-MS) was recently developed by Hu et al.
The organizations asked: Of the environments where mass spectrometry
tools ARE NOT currently in use, in which ones would you like to see the technology take hold by 2020?
"Scientists all over the world have made tremendous scientific progress over the past decade using Orbitrap- based mass spectrometry
with liquid chromatography, said Sergio Guazzotti, director of marketing, GC-MS, Thermo Fisher Scientific.
According to Kalorama, one of the key strengths of these types of mass spectrometry
is that they avoid traditional tissue sample preparation.
These researchers have developed methods quantifying light chains using electrospray quadrupole-time-of-flight mass spectrometry
, which provides a rapid analysis with improved sensitivity and molecular specificity (due to the measurement of the intact molecular weight) compared to protein electrophoresis (7).
"The fact that my research group, which studies infectious diseases, has access to these powerful imaging and mass spectrometry
technologies is a real strength at Vanderbilt and has allowed us to develop these new tools that will enable high impact discovery," Skaar said.
They consider such topics as ion mass spectrometry
with a focus on lipids, mapping pharmaceuticals in rat brain sections using MALDI imaging mass spectrometry
, tandem mass spectrometric methods for phospholipid analysis from brain tissue, tissue protein identification improvement by N-terminal peptide derivatization, the multivariate statistical treatment of imaging data for clinical biomarker discovery, and mass spectrometry
imaging using the stretched sample approach.