Allele-counting schemes for discordant half sib pairs Case Half sib genotypes Alleles counted Scheme 1 Scheme 2 1 11 11 1,1 1,1 -- -- 2 11 12 1,1 1,2 1 2 3 11 22 1,1 2,2 1,1 2,2 * 1 and 2 represent distinct alleles at the marker locus
Our TDT analysis did not reveal any significant association when we analyzed a marker locus
at a time.
Patients with a homozygous mutation may not have the same allele size at the selected marker locus
if the 2 mutant alleles do not have a common origin (3).
The expected value of y can be expressed as a conditional expectation, given the allele M at a molecular marker locus
His analysis has shown that associative overdominance is most strongly expressed in the simultaneous presence of both inbreeding and linkage disequilibrium between the marker locus
and tightly linked deleterious genes.
Chi-square tests were performed for each marker locus
to determine if the segregation ratio conformed to 1:1.
eR]) acting on each marker locus
can be estimated from [s.
0-LOD support intervals, genetic marker intervals spanning QTL peaks, closest genetic marker locus
to the QTL peak, phenotypic coefficients of determination ([R.
Genotypic effects were estimated for each marker locus
, and all pairwise combinations of loci on different chromosomes (N = 2443) were tested for two-locus epistasis.
All genotypes had the recessive allele at the marker locus
Satt557, therefore, its genotype is e1 and probably e7 since these loci are tightly linked (Cober and Voldeng, 2001).
He reasoned that if the marker locus
is under overdominant selection, then allele frequencies at equilibrium are known functions of genotypic fitness values.
Moreover, epistatic pairs of QTL are fit directly at marker locus
positions rather than in intervals, which may reduce the power of QTL epistasis tests compared to the additive effect tests.