marimastat


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marimastat

A matrix metalloproteinase and angiogenesis inhibitor which had shown early promise for managing advanced malignancy; phase-III studies failed in this expectation, however. Marimastat may have a secondary role as maintenance therapy for advanced colorectal, ovarian, pancreas, prostate and other cancers.
 
Adverse effects
Musculoskeletal pain.

marimastat

Oncology An angiogenesis inhibitor and matrix metalloproteinase inhibitor in clinical trials as an ancillary therapy for advanced malignancy–ovary, pancreas, small cell of lung, stomach, glioblastoma. See Angiogenesis inhibitors.
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Figure 6 shows the structures of the [sPLA.sub.2] inhibitor, varespladib, and other SMT candidates that could be repurposed, the anti-svMP peptidomimetic SMTs, prinomastat, and marimastat [17,18, 54].
Developing Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite
Kubota et al., "Matrix metalloproteinase inhibitor, marimastat, decreases peritoneal spread of gastric carcinoma in nude mice," Cancer Science, vol.
Establishment and Characterization of a Nude Mouse Model of Subcutaneously Implanted Tumors and Abdominal Metastasis in Gastric Cancer
Over the last few years, antiproteolytic approach in antifibrotic therapies was restricted mainly to matrix metalloproteinases activity; however, broad range MMP inhibitors like marimastat and prinomastat failed clinical tests, as they led to severe side effects [21, 22].
Proteases Revisited: Roles and Therapeutic Implications in Fibrosis
In a clinical trial, conducted on patients affected by chemotherapy refractory advanced gastric cancer and gastroesophageal cancer, the MMP marimastat only determined a little difference in survival.
Diagnostic, Predictive, Prognostic, and Therapeutic Molecular Biomarkers in Third Millennium: A Breakthrough in Gastric Cancer
The MMP inhibitors batimastat and marimastat reduce CNV when applied early in the process [93,94], suggesting a potential therapeutic role for MMP9 inhibitors in AMD.
Integrated Approaches to Drug Discovery for Oxidative Stress-Related Retinal Diseases
Hambley, "Studies of a cobalt(III) complex of the MMP inhibitor marimastat: a potential hypoxia-activated prodrug," Chemistry, vol.
Synthesis, crystal structure, and thermal decomposition of the Cobalt(II) complex with 2-picolinic acid
Agents that are MMPs enzyme inhibitors (batimastat, marimastat) and agents that alter vascular endothelial cells MMPs expression currently are being evaluated as angiostaticagents (16).
Impact of altered expression of matrix metalloproteinases (MMPs) on the development and severity of diabetic retinopathy
Although this design hasproducedpotentinhibitorssuchasBatimastat[11, 12] and Marimastat [13](Figure 1), none of these MMPIs has successfully completed clinical trials.
Amino acid derivatives as new zinc binding groups for the design of selective matrix metalloproteinase inhibitors
The matrix metalloproteinase inhibitor Marimastat (Tocris Bioscience, Bristol, United Kingdom) was used at 10 [micro]M final concentration.
Cell matrix remodeling ability shown by image spatial correlation
British Biotech was humbled in the late 1990s when its leading drug hope, a cancer treatment called Marimastat, failed clinical trials.
Biotech and Vernalis merge
A recent trial evaluating the combination of marimastat (a protease inhibitor) and temozolomide reported a 6-month progression-free survival of 39% compared to 21% with temozolomide alone (Groves et al., 2002).
Glial tumors--new approaches in chemotherapy. (Pharmacology Update)
Once one of the bright lights of the UK sector, it was hit by the failure of cancer drug Marimastat and pancreatitis treatment Zacutex, both at one point hailed as potential blockbusters.
Drugs firms' merger is off

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