marginal zone lymphoma


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marginal zone lymphoma

a heterogeneous group of neoplasms originating from the B-cell-rich zones of the lymph nodes, spleen, or extranodal lymphoid tissue. Those tumors originating from mucosa-associated lymphoid tissue (MALT), most often in the stomach, intestines, salivary glands, and lungs, are called MALTomas.

mar·gi·nal zone lym·pho·ma

(mahr'ji-năl zōn lim-fō'mă)
A heterogeneous group of neoplasms originating from the B cell-rich zones of the lymph nodes, spleen, or extranodal lymphoid tissue. Those tumors originating from mucosa-associated lymphoid tissue (MALT), most often in the stomach, intestines, salivary glands, and lungs, are called MALTomas.
References in periodicals archive ?
A representative case of primary ocular adnexal marginal zone lymphoma with MYD88 L265P mutation and [IgA.sup.+] plasma cells or plasmacytoid lymphocytes.
[2] reported that there were six primary lymphomas: three extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT) type and three diffuse large B-cell lymphomas.
- The US Food and Drug Administration approved Revlimid (lenalidomide) in combination with a rituximab product for the treatment of adult patients with previously treated follicular lymphoma or marginal zone lymphoma following Priority Review designation, US-based Celgene Corp.
Cutaneous marginal zone lymphomas. Semin Diagn Pathol.
The FDA had previously granted copanlisib fast track designation in FL as well as Orphan Drug designation for the treatment of patients with FL and for the treatment of splenic, nodal, and extranodal subtypes of marginal zone lymphoma.
Non-Hodgkin lymphoma of the breast is exceedingly rare; the majority diagnosed are of B-cell origin including diffuse large B-cell lymphoma, extranodal marginal zone lymphoma, follicular lymphoma, primary effusion lymphoma, and lymphoplasmacytic lymphoma [5-7].
The MYD88 L265P variant was absent in bone marrow from healthy donors and absent or rarely expressed in marrow samples from patients with marginal zone lymphoma (MZL), IgM monoclonal gammopathy of undetermined significance (MGUS), and IgM multiple myeloma [4, 5].
In the gastrointestinal tract, the diagnosis of plasmacytoma or myeloma with extramedullary involvement should be made after excluding the more common involvement of non-Hodgkin lymphoma with plasmacytic differentiation specially extranodal marginal zone lymphoma of mucosa associated lymphoid tissues (MALT lymphoma) and lymphoplasmacytic lymphoma (LPL) in cases with bland appearance and plasmablastic lymphoma in case of anaplastic myeloma.
The third group of MBL is CD5(−) which has a similar immunophenotype with splenic marginal zone lymphoma.[sup][1] As for the patient described in our case, flow cytometry (FCM) showed CD5(−), CD10(−), CD19(+), and FMC7(+), which should be assigned into the CD5(−) MBL with an origin from the marginal zone lymphoid tissue.
The "marginal zone-like" variant has prominent foci of cells with abundant pale cytoplasm resembling marginal zone or monocytoid B cells seen in marginal zone lymphoma [10].
INTRODUCTION: Splenic Marginal Zone Lymphoma (SMZL) is the term coined by Schmid et al.
Findings on pathologic examination were consistent with extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma).