fire-flare appearance

(redirected from marginal vacuoles)

fire-flare appearance

A term referring to the light microscopic appearance of colloid at the edge of thyroid follicles which has been fancifully likened to flickering flames. The pattern is best appreciated in Giemsa-stained fine-needle aspiration (FNA) smears from thyroid aspirates. It was first described as a distinctive feature of thyrotoxic goiter and hyperthyroidism, but later found in non-neoplastic (e.g., Graves’ disease) and neoplastic thyroid lesions. Scattered reports to the contrary, marginal vacuoles probably have little diagnostic utility.
References in periodicals archive ?
Various cyto morphological features including predominant cell pattern, cell morphology, background and marginal vacuoles are taken into account for diagnosing various lesions.
The Diagnostic Role of the Marginal Vacuoles in FNAC of Solitary Thyroid Nodule.