The importance of radial
margin involvement in colon cancer has not been as carefully studied compared with rectal cancer.
The relationship between surgical
margin involvement and histopathological findings is shown in Table 3.
Patients presenting with advanced tumors with peritoneal involvement or circumferential
margin involvement may benefit from incorporation of intensive systemic therapy as part of their neoadjuvant course.
A case series of 13 patients with periocular AK treated with 5-FU for 14 days, twice a day, 9 of which with eye
margin involvement, reported complete resolution at final follow-up.
The risk factors for locoregional recurrence include the stage of primary cancer [2-5], location of primary cancer, emergent surgery [2, 3], lymph-vascular invasion [4, 5], bowel perforation [3, 5], bowel obstruction,
margin involvement, and local tumor invasion [5].
A comparison of published rates of resection
margin involvement and intra-operative perforation between standard and 'cylindrical' abdominoperineal excision for low rectal cancer.
We also did not find any significant correlation between
margin involvement and maspin or ezrin expression (P = 0.12 and 0.058, resp.).
Moreover, this technique has been used to remove rectal carcinoid tumors and has demonstrated a superior efficacy to conventional endoscopic mucosal resection (EMR), particularly for less vertical
margin involvement [16, 17].
Recurrent cases of BCC tend to have a more aggressive course.10 The rates of recurrence appear to depend to a large extent on the anatomical localization the histological characteristics the initial treatment strategy and the eventual neoplastic
margin involvement. A variety of therapeutic options e.g.
His histopathological report was a well differentiated squamous cell carcinoma with
margin involvement. There was also involvement of the thyroid cartilage, thyroid capsule and gland for which he subsequently underwent radiotherapy.
Margin involvement was determined by the local pathologist at the hospital.