marenostrin

py·rin

(pī'rin),
An abnormal neutrophil protein encoded by the MEFV gene in familial Mediterranean fever.
Synonym(s): marenostrin

marenostrin

A 781-residue protein encoded by MEFV that modulates innate immunity and is thought to control the inflammatory response in myelomonocytic cells at the level of cytoskeletal organisation.

Molecular pathology
Mutations in MEFV are associated with Mediterranean fever.

py·rin

(pī'rin)
An abnormal neutrophil protein encoded by the MEFV gene in familial Mediterranean fever.
Synonym(s): marenostrin.
References in periodicals archive ?
The disease-causing gene (MEFV) encodes for a protein called pyrin also known as marenostrin (Marenostrum: Mediterranean).
Familial Mediterranean fever (OMIM 249100) is transmitted by autosomal recessive inheritance and, in its most frequent and classic phenotype, is characterized by recurrent acute fever episodes, polyserositis, arthritis, and erysipelas-like erythema [15]: it is due to the presence of mutations (among the 200 identified to date) in the MEFV (from MEditerranean FeVer) gene which encodes the protein pyrin, also known by its Europeanname "marenostrin" [16, 17](Table 1).
MEFV provides instructions for the cellular production of a protein named pyrin, also known as marenostrin. (5,6) When nonsense or missense mutations in the MEFV gene occur, pyrin becomes either mutated or not produced.
(1,2) Pyrin or marenostrin are products of the Mediterranean fever (MEFV) gene, a regulatory protein that is mainly expressed in neutrophils.