maprotiline


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maprotiline

 [mah-pro´tĭ-lēn]
a tetracyclic antidepressant administered orally as the hydrochloride salt for relief of symptoms of depression. It acts by blocking the reuptake of norepinephrine at nerve terminals; unlike tricyclic antidepressants, it has no effect on serotoninergic transmission.

maprotiline

A tetracyclic antidepressant similar to tricyclic agents.
 
Indications
Major depression, bipolar disorder.

Adverse effects
Anticholinergic effects (e.g., dizziness, drowsiness, fatigue, dry mouth), orthostatic hypotension, sinus tachycardia or other arrhythmias, sexual dysfunction, rash, photosensitivity, confusion, seizures, liver toxicity, agranulocytosis, polyneuritis and other findings.

Special considerations
Should not be administered with MAOIs; may be toxic to the liver or kidneys; may cause seizures; may cause arrhythmias or heart failure.

maprotiline

Ludiomil® Neuropharmacology A tetracyclic antidepressant similar to tricyclic agents Indications Major depression, bipolar disorder. See Tricyclic antidepressant.
References in periodicals archive ?
Neurobiochemical aspects of maprotiline (Ludiomil) action.
The National Pregnancy Registry for Antidepressants (844-405-6185) is studying amitriptyline (Elavil), amoxapine (Asendin), bupropion (Forfivo XL and Wellbutrin), Citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), desvenlafaxine (Prisiq), doxepin (Sinequan), escitalopram (Lexapro), fluvoxamine (Luvox), fluoxetine (Prozac), imipramine (Tofranil), isocarboxazid (Marplan), levomilnacipran (Fetzima), maprotiline (Ludiomil), mirtazapine (Remeron), nefazodone (Serzone), nortriptyline (Pamelor), paroxetine (Paxil), phenelzine (Nardill), protriptyline (Vivactil), selegiline (Emsam), sertraline (Zoloft), tranylcypromine (Parnate), trazodone (Desyrel), trimipramine (Surmontil), venlafaxine (Effexor), and vilazodone (Viibryd).
Maprotiline induced weight gain in depressive disorder: changes in circulating ghrelin and adiponectin levels and insulin sensitivity.
Effects of fluoxetine and maprotiline on functional recovery in post-stroke hemiplegics patients undergoing rehabilitation therapy.
At the time of examination he was on a course of maprotiline hydrochloride 75 mg/d, sodium valproate 600 mg/d sustained release tablets, flunitrazepam 1 mg/d, and lorazepam 2 mg/d, prescribed by a psychiatry department of another hospital.
While imipramine, amitriptiline, nortriptiline, desipramine, maprotiline and doxepin can pot considerably prolong QTc, clinical studies have shown only a slight prolongation of QTc with the use of clomipramine, mirtazapine and trazodone and especially in cases of trazodone overdose.
(8.) Guimaraes FS, Zuardi AW, Graeff FG: Effect of chlorimipramine and maprotiline on experimental anxiety in humans.
Graeff, "Effect of chlorimipramine and maprotiline on experimental anxiety in humans," Journal of Psychopharmacology, vol.
Did not observe use of the following antidepressants: Amoxapine, Clomipramine, Imipramine, Maprotiline, Protriptyline, Trimipramine, Vilazodone, Vortioxetine, and Nefazodone.
Antidepressant n % Tricyclic (N06AA) 110 76.4 Amitriptyline (N06AA09) 50 34.7 Imipramine (N06AA 02) 20 13.9 Nortriptyline (N06AA 10) 14 9.7 Maprotiline (N06AA 21) 11 7.6 Clomipramine (N06AA 04) 8 5.6 Amineptine (N06AA 19) 7 4.9 The SSRI (a) (N06AB) 26 18.1 Fluoxetine (N06AB03) 19 13.2 Paroxetine (N06AB05) 5 3.5 Sertraline (N06AB06) 2 1.4 MAOI (b) (N06AF and N06AG) 8 5.6 Moclobemide (N06AG02) 6 4.2 Tranylcypromine (N06AF04) 2 1.4 (a) Serotonin selective recapture inibitor.
The potential risk of fracture presented by class of psychotropic medications Class of drug Lowest risk Moderate risk Highest risk Anticonvulsants Lamotrigine Carbamazepine Phenytoin Valproic acid Antidepressants Maprotiline Amitriptyline Citalopram Mirtazapine Desipramine Fluoxetine Tranylcypromine Doxepin Fluvoxamine Nefazodone Imipramine Nortriptyline Paroxetine Trazodone Sertraline Venlafaxine Antipsychotics Aripiprazole lloperidone Haloperidol Asenapine Lurasidone Paliperidone Clozapine Olanzapine Risperidone Quetiapine Typical Ziprasidone antipsychotics (all) Lithium May be protective but evidence is insufficient The authors' observations