mantle-zone lymphoma

mantle-zone lymphoma

Mantle cell lymphoma A low-to-intermediate grade B cell lymphoma by the Working Formulation, which accounts for 1-8% of NHLs, and is most common in ♂ ≥ age 55; it characterized by a proliferation of small lymphocytes in the mantle zone, surrounding benign germinal centers; MZLs are often aggressive and involve the spleen, liver, BM, etc Clinical Massive splenomegaly, generalized lymphadenopathy,13 present with 'type B' symptoms–eg, fever, weight loss, night sweats Median survival 31 months; 40% achieve complete remission with chemotherapy. See Lymphoma.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.