mantle zone


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Related to mantle zone: Mantle Zone Lymphoma

man·tle zone

1. Synonym(s): mantle layer
2. a layer of small B lymphocytes surrounding the paler-staining germinal centers of lymphoid follicles.
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
As in our patient, mantle zone growth pattern and a Ki-67 index < 10% suggest a favorable prognosis.
A, The MCL shows mantle zone and diffuse growth pattern.
[2] cervical, and right perirenal lymphadenopathies HHV8+, EBV+ HCV+, HIV- M/61 Submandibular, Preserved inguinal, architecture and paratracheal germinal centers M/61 lymphadenopathies were replaced HHV8+, EBV+, HIV- partially or completely by tumor cells: plasmablasts and anaplastic cells Normal mantle zones Prominent plasmacytosis in the interfollicular zones F/63 Left leg swelling and paraesthesia para-aortic lymphadenopathy Not available Taris et F/49 Isolated jugular Nodular al.
The characteristics of mucous secreted by the gland cells, a group of cells that compose the mantle epithelial layer, are reported to differ slightly from species to species and in the mantle zone. Although the chemical composition of mucous substances generated in the mantle varies greatly, they are composed mainly of mucopolysaccharides, glycoproteins, and carbohydrates (Prezant 1981).
Reactive follicles may show variability in size and shape but typically exhibit polarized germinal centers that are made up of centroblasts and centrocytes with admixed tingible body macrophages and small mature lymphocytes, which are cuffed by well-formed and defined mantle zone (Figure 2, B and C).
The mantle zone around these follicles is often diminished or absent.
The reactive lymphoid follicles comprise germinal centers with polarity and tingible-body macrophages, and the germinal centers are surrounded by the mantle zone with small mantle cells; the marginal zone with monocytoid lymphocytes is located outside of the mantle zone in the parafollicular area and is usually not prominent in the lymph nodes.
Neoplastic follicles are poorly defined; they lack a mantle zone and polarization; they have few mitotic figures; and they tend to lack tingible-body macrophages.
Cellular proliferations of mantle cell lymphoma typically are most evident in the perifollicular area surrounding residual germinal centers in the mantle zone pattern or may diffusely efface the lymph node architecture.
In fact, even floridly reactive germinal centers sometimes contain large vesicular nuclei and lack a well-defined mantle zone. The differential considerations can often be confirmed by a pertinent immunohistochemistry panel.
The CD20+ mantle zone lymphocytes are expanded and arranged in a distinctive concentric "onion-skin" fashion (Figure 2).