mantle cell lymphoma


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mantle cell lymphoma

a clinically and biologically distinct B-cell neoplasm with a recurring acquired genetic abnormality, the t(11;14) translocation, and a heterogeneous histologic appearance that may lead to confusion with reactive or other neoplastic lymphoproliferative disorders.
Farlex Partner Medical Dictionary © Farlex 2012

mantle cell lymphoma

An uncommon low-to-intermediate-grade non-Hodgkin lymphoma (NHL), which is a malignancy of naive B cells. It comprises ± 6% of NHL cases in the US, slightly higher in Europe. It is hard to treat and harder to cure. It is more common in men ≥ age 55.
 
Clinical findings
Massive splenomegaly, generalised lymphadenopathy, 1/3 present with “B” symptoms—i.e., fever, weight loss, night sweats.

Sites
Nodes, spleen, bone marrow, Waldeyer's ring, GI (lymphomatous polyposis), gallbladder. 

DiffDx
• Small lymphocytic lymphoma/CLL
• MALT lymphoma
• Follicular lymphoma

Prognosis MCLs are often aggressive and involve the spleen, liver, bone marrow; they are regarded as incurable. Median 2- to 5-year survival. Cases with mutations in the immunoglobulin gene have better prognosis—40% achieve complete remission with chemotherapy.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

man·tle cell lym·pho·ma

(man'tĕl sel lim-fō'mă)
A clinically and biologically distinct B-cell neoplasm with a recurring acquired genetic abnormality, the t(11;14) translocation, and a heterogeneous histologic appearance that may lead to confusion with reactive or other neoplastic lymphoproliferative disorders.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
The Study Explore the Product Types of Mantle Cell Lymphoma Therapeutics Market: , Combination Therapy & Monotherapy
Brown et al., "Real world data on primary treatment for mantle cell lymphoma: A Nordic Lymphoma Group observational study," Blood, vol.
(4.) Cheah CY, George A, Gine E, Chiappella A, Kluin-Nelemans HC, Jurczak W, Krawczyk K, Mocikova H, Klener P, Salek D, Walewski J, Szymczyk M, Smolej L, Auer RL, Ritchie DS, Arcaini L, Williams ME, Dreyling M, Seymour JF; European Mantle Cell Lymphoma Network.
Zwingers et al., "Improvement of overall survival in advanced stage mantle cell lymphoma," Journal of Clinical Oncology, vol.
* The report provides a snapshot of the global therapeutic landscape of Mantle Cell Lymphoma
Non-multiple lymphomatous polyposis form of mantle cell lymphoma in the gastrointestinal tract.
Based on these parameters, the patient's mantle cell lymphoma international prognostic index score was calculated as 1 (low risk 0-3).
Keywords: Mantle cell lymphoma (MCL), Diffuse large B-cell lymphoma (DLBCL), Chronic lymphocytic leukaemia (CLL), Follicular lymphoma (FL), Complete remission (CR), Partial response (PR), Non-Hodgkin lymphoma (NHL).
Campo, "Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics," Nature Reviews Cancer, vol.
The book examines new and emerging therapies for Hodgkin and non-Hodgkin lymphoma, T-cell lymphoma, indolent lymphoma, mantle cell lymphoma, and aggressive B-cell lymphoma.
1, at Brigham and Women's Hospital, Boston, after a battle with mantle cell lymphoma.