mannose-binding protein

mannose-binding protein

a protein involved in innate immunity that can bind mannosylated microorganisms and activate the complement pathway.

mannose-binding protein

A protein encoded by MASP1 on chromosome 3q27-q28, and found in the serum and liver, which mediates innate antimicrobial defence by binding to specific cell surface high mannose oligosaccharides of various bacteria, fungi and possibly also viruses (e.g., HIV), killing them by complement-mediated cell lysis or opsonisation.

man·nose-bind·ing pro·tein

(man'ōs bīnd'ing prō'tēn)
A protein involved in innate immunity that can bind mannosylated microorganisms and activate the complement pathway.
References in periodicals archive ?
Cheng, "Molecular defects in variant forms of mannose-binding protein associated with immunodeficiency," Journal of Immunology, vol.
Fujita, "Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease," The Journal of Experimental Medicine, vol.
Multivalent ligand binding by serum mannose-binding protein. Arch Biochem Biophys 1992; 299: 129-136, doi: 10.1016/0003-9861(92)90254-T.
Assessment of measuring circulating levels of interleukin-6, interleukin-8, C-reactive protein, soluble Fc gamma receptor type III, and mannose-binding protein in febrile children with cancer and neutropenia.
Mannose-binding protein B allele confers protection against tuberculous meningitis.
Engineering galactose-binding activity into a C-type mannose-binding protein. Nature 360: 183-186.
Factors responsible for this relative resistance to infection and disease include cytotoxic T cells, neutralizing antibodies, high concentrations of certain chemokines (e.g., RANTES, MIP-1), human leukocyte antigen haplotype, mannose-binding protein, and tumor necrosis factor alpha, C4, and TAP polymorphism (2-4).
A total of 14 spots were identified as follows: serotransferrin (TRFE spots 1 and 2), albumin (ALBU, spot 3 as a fragment), kininogen-1 (KNG1, spot 4), alpha-fetoprotein (FETA, spot 5), mannose-binding protein C (MBL2, spot 6), apolipoprotein A1 (APOA1, spots 7 and 8), alpha-1-antitrypsin (A1AT, spots 9, 10, and 11), CD5 antigen-like (CD5L, spot 12), alpha-2-macroglobulin (A2M, spot 13), and vitamin D-binding protein (VTDB, spot 14).
A human serum mannose-binding protein inhibits in vitro infection by the human immunodeficiency virus.
Analytical evaluation of particle-enhanced immunonephelometric assays for C-reactive protein, serum amyloid A and mannose-binding protein in human serum.
Day et al., "The human mannose-binding protein gene.

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