One approach is the targeting of specific sugar receptors expressed on several cancer cells, the mannose and mannose-6-phosphate receptors
. The new publication in Advanced Health Materials presents first results of a new approach tested in the Merkel Lab.
Phagolysosomes are also characterized by a PI(3)P-enriched internal membrane [166, 167] and by the lack of mannose-6-phosphate receptors
The IGF-II receptor (IGF-IIR), which is homologous to the cation-independent mannose-6-phosphate receptor
, has a high affinity for IGF-II .