mannose-6-phosphate receptors

man·nose-6-phos·phate re·cep·tors (MPR),

receptors in Golgi apparatus to which newly synthesized proteins that are destined to enter lysosomes bind.
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One approach is the targeting of specific sugar receptors expressed on several cancer cells, the mannose and mannose-6-phosphate receptors. The new publication in Advanced Health Materials presents first results of a new approach tested in the Merkel Lab.
Phagolysosomes are also characterized by a PI(3)P-enriched internal membrane [166, 167] and by the lack of mannose-6-phosphate receptors [168].
The IGF-II receptor (IGF-IIR), which is homologous to the cation-independent mannose-6-phosphate receptor, has a high affinity for IGF-II [65].