mannan-binding protein

mannan-binding protein

A protein encoded by MBL2 on chromosome 10q11.2-q21 belonging to the collectin family in the C-type lectin superfamily, which plays a role in carbohydrate pattern recognition as the first line of immune defence in a non-immunised (pre-immune) host. MBP recognises patterns on the surface of a wide range of pathogens—i.e., bacteria, viruses, protozoa and fungi; binding of MBP to a microbe activates the lectin pathway of the complement system. MBP also binds senescent and apoptosing cells, and enhances their engulfment by phagocytes.
Mentioned in ?
References in periodicals archive ?
Dual role of mannan-binding protein in infections: another case of heterosis?
Antitumor activity of mannan binding protein in vivo as revealed by a virus expression system: mannan-binding protein dependent cell-mediated cytotoxicity.
Interplay between promotor and structural gene variants control basal serum level of mannan-binding protein. J Immunol 1995;155:3013-20.
Turner, "Association of low levels of mannan-binding protein with a common defect of opsonisation," The Lancet, vol.
Diallelic polymorphism may explain variations of the blood concentration of mannan-binding protein in Eskimos, but not in black Africans.
Association of low levels of mannan-binding protein with a common defect of opsonisation, Lancet, 1989,.
Interplay between promoter and structural gene variants controls basal serum level of mannan-binding protein, J Immunol, 1995, pg.
Kurtzhals et al., "A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein," Immunogenetics, vol.
Yamashina, "Subcellular distribution of the mannan-binding protein and its endogenous inhibitors in rat liver," Archives of Biochemistry and Biophysics, vol.
Sim, "Mannan-binding protein levels in human amniotic fluid during gestation and its interaction with collectin receptor from amnion cells," Immunology, vol.