Melmed, "Expression of three somatostatin receptor subtypes in pituitary adenomas: evidence for preferential SSTR5 expression in the mammosomatotroph
lineage," The Journal of Clinical Endocrinology and Metabolism, vol.
The aim of this study was to evaluate the effect of methylmercury on prolactin release and the role of the nitrergic system, using an experimental model of the rat mammosomatotroph cell line, GH3B6 prolactin secretory cells.
MeHg exposure of cells of a mammosomatotroph origin showed a relevant cytotoxic effect only when the highest concentration was used (100 [micro]M).
hyperplasia associated with acromegaly and hyperprolactinemia in a patient with the McCune-Albright syndrome.
(13) In the literature, a distinction had been made between mixed GH-PRL and mammosomatotroph
adenomas, especially at large specialty referral institutions, such as that of one of the authors (M.B.S.L.), (13) but this requires availability of, and expertise in interpreting, electron microscopy.
In a surgical series of 117 patients with PAs, only 3 cases (2.6%) had double PAs and 1 had concomitantly a somatotrophinoma and a silent mammosomatotroph
adenoma, whereas in the other 2 cases, coexistent lactotroph and null-cell adenomas were noted.
Subclassification of GHand prolactin-producing adenomas as densely granulated somatotroph adenomas with prolactin content, mammosomatotroph
adenomas, or mixed somatotroph-lactotroph adenomas can be difficult without ultrastructural analysis, but the significance of these subtleties for clinical management remains unclear.