maspin

(redirected from mammary serine protease inhibitor)

maspin

A 42-kD tumour suppressor protein of the serpin superfamily, encoded by SERPINB5 on chromosome 18q21.3. Despite its name, maspin (mammary serine protease inhibitor) has no serine protease inhibitory activity.

Normal expression
Various epithelial cells.

Abnormal expression
Downregulated in breast, prostate and colorectal carcinomas; upregulated in pancreatic, gastric and ovarian cancers.