malondialdehyde-modified LDL

malondialdehyde-modified LDL

A low-density lipoprotein, which is chemically modified in vivo, thought to reflect naturally occurring oxidation of LDL and serve as a surrogate marker for significant atherosclerosis; it is thus useful as a biochemical marker of coronary artery disease.
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References in periodicals archive ?
Collen, "Oxidized LDL and malondialdehyde-modified LDL in patients with acute coronary syndromes and stable coronary artery disease," Circulation, vol.
Van de Werf, "Malondialdehyde-modified LDL as a marker of acute coronary syndromes," The Journal of the American Medical Association, vol.
Beneficial effects of grape seed extract on malondialdehyde-modified LDL. J Nutr Sci Vitaminol (Tokyo).
Inoue et al., "Increased circulating malondialdehyde-modified LDL levels in patients with coronary artery diseases and their association with peak sizes of LDL particles," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
Sato et al., "Circulating malondialdehyde-modified LDL and atherogenic lipoprotein profiles measured by nuclear magnetic resonance spectroscopy in patients with coronary artery disease," Atherosclerosis, vol.
Lopes-Virella and her colleagues measured the levels of oxidized LDL (Ox-LDL), advanced glycated end product LDL (AGE-LDL), and malondialdehyde-modified LDL (MDA-LDL) in immune complexes that were isolated from the baseline serum samples, and compared those levels with the ultrasound measurements at both time points.
However, assays based on sandwich ELISAs have been developed mainly for oxLDL and its isoform, malondialdehyde-modified LDL (MDA-LDL), by several groups (15,32,33,48,49).
[4] Nonstandard abbreviafions: oxLDL, oxidized LDL; gLDL, glycated LDL; acLDL, acetylated LDL; ApoB, apolipoprotein B; cLDL, carbamylated LDL; nLDL, native LDL; HRP, horseradish peroxidase; BSA, bovine serum albumin; PBS, phosphate-buttered saline; PBS-E, PBS with EDTA; SDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis; TC, total cholesterol; and MDA-LDL, malondialdehyde-modified LDL.
We previously reported that malondialdehyde-modified LDL (MDA-LDL) is distributed to small dense LDL fractions by density gradient ultracentrifugation (7).
[5] Nonstandard abbreviations: IDL, intermediate-density lipoprotein; TG, triglyceride; HDL-C, HDL-cholesterol; MDA-LDL, malondialdehyde-modified LDL; apo A-1 and B, apolipoprotein A-1 and B; DM, diabetes mellitus; HbA1c, glycosylated hemoglobin; TC, total cholesterol; TBARS, 2-thiobarbituric acidreactive substances; and CHD, coronary heart disease.
Malondialdehyde-modified LDL has been shown to stimulate formation of autoantibodies, and immune complexes of LDL aggregates are efficiently internalized by macrophages via Fc receptors, further promoting cholesterol accumulation.