Von Hippel-Lindau disease (VHL), also known as Familial cerebello retinal angiomatosis, is a rare genetic disorder characterised by visceral cysts and benign tumours with potential for subsequent malignant transformation
If the patient chooses to clinically monitor the lesion, he or she should be informed that a full-thickness excision with wide margins will have to be performed if malignant transformation
2] Thus, OSCC constitutes a major health challenge with increased need for research and identification of biomarkers which can help predict malignant transformation
EVER genes are transcribed in human skin keratinocytes, T lymphocytes, B lymphocytes, and NK cells, thereby impairing CMI and causing persistence of EV-associated HPV types and uncontrolled proliferation of stem cells and transient amplifying cells infected with HPV5 and HPV8, causing malignant transformation
of some lesions (1, 2).
of multiple familial trichoepithelioma: case report and literature review.
The plethora of histopathological presentations of SP is further complicated by malignant transformation
in about 11% of patients of IP, the malignancy can be synchronous or may appear after resection of papilloma (metachronous).
2] A malignant tumour that arises in a pre-existing mature teratoma is called teratoma with malignant transformation
,  which occurs in 1-3% of all mature teratomas.
9) No follow-up studies have been published, but based on the lack of literature demonstrating recurrence or malignant transformation
after removal, it has been accepted that removal is the standard of care.
Objective: To determine the relationship of age, gender and other associated risk factors linked with malignant transformation
of oral submucous fibrosis into oral squamous cell carcinoma.
Objective: Multiple myeloma (MM) represents a unique model to investigate cancer stem cells (CSCs), circulating tumour cells (CTCs), and the mechanisms of malignant transformation
According to the theory by Vogelstein, colorectal carcinogenesis involves a series of successive changes in the normal colonic mucosa, starting with excessive proliferation and focal disorders of intestinal crypts, followed by adenoma and its subsequent malignant transformation
Oral submucous fibrosis (OSF) is a chronic, progressive condition attributed chiefly to areca nut (betel nut) chewing and carries significant potential for malignant transformation