malignant transformation


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malignant transformation

The constellation of changes in the growth properties of cells in culture evoked by various agents (e.g., radiation, toxins and viruses) that result in development of neoplasms with metastatic potential. The ability to metastasise is generally regarded as the defining marker of a tumour as being malignant.

malignant transformation

Oncology The constellation of changes in the growth properties of cells in culture evoked by various agents–eg, radiation, toxins, and viruses that result in development of tumors
References in periodicals archive ?
Much work has been done and debates about the malignant transformation of SCAP are ongoing.
Although they are usually benign, some cases of malignant transformation have been reported (3).
In collaboration with Beijing Stomatological Hospital affiliated with the Capital Medical University in China, Avalon and Genexosome Technologies have completed a clinical study and revealed miR185 as a novel saliva-based exosomal biomarker with strong correlation and predictive value for malignant transformation from oral leukoplakia to oral cancer.
* Malignant transformation in such a tumour is very rare, evidenced by regional or distant metastasis, [4] unusual finding (only 39 cases have been documented in the English language literature till date).
FNAC was performed on the mass, which confirmed it to be PA with marked nuclear atypia suspicious for malignant transformation.
(15) When histologic grades were combined into 2 groups, the malignant transformation rate was higher in the severe dysplasia-CIS group (30.4%) than in the mild to moderate dysplasia group (10.6%).
Malignant transformation is estimated to be 7%, and the recurrence is approximately 15% [3].
However, rare cases with adenomatous and even malignant transformation have been reported.
Von Hippel-Lindau disease (VHL), also known as Familial cerebello retinal angiomatosis, is a rare genetic disorder characterised by visceral cysts and benign tumours with potential for subsequent malignant transformation.

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