malignant mimic

malignant mimic

A generic term for a non-malignant lesion with an aggressive, malignant appearance.

Endoscopic lesions mimicking malignancy include “ragged”, well-circumscribed ulcers that histologically appear in an amorphous eosinophilic background, with sheets of closely packed acini, cells with swollen granular cytoplasm, variably-sized, often hyperchromatic nuclei, mitotic activity and a lesion that fades into benign regenerative mucosa.

Other endoscopic malignant mimics seen in the oesophagus, stomach and rectum consist of fibrinopurulent exudate, which covers aggregates of bizarre cells with variable amounts of granular cytoplasm, hyperchromatic pleomorphic nuclei. 

A lesion that grossly or microscopically mimics malignancy, which may be induced by inflammation, radiation therapy, chemotherapy, and evoke cytologic features of malignant lesions.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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Fine-needle aspiration of soft tissue perineurioma: A comparative analysis of cytomorphology and immunohistochemistry with benign and malignant mimics. Cancer Cytopathol 2016;124:6518.
Part 2 in the September issue will include 3 articles: Graham Slack, MD, has prepared an article titled "The Pathology of Reactive Lymphadenopathies: A Discussion of Common Reactive Patterns and their Malignant Mimics"; Allen Gown, MD, has written "Diagnostic Immunohistochemistry: What Can Go Wrong and How to Prevent It"; and Kasmintan Schrader, MBBS, PhD, and colleagues have written "How to Screen for Hereditary Cancers in General Pathology Practice."
Once again, it is the lack of significant nuclear pleomorphism, cytologic atypia, and abnormal mitoses that most clearly separates IMT from its malignant mimics. The slitlike vascularity typical of IMTs is not seen in LMSs.

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