malignant mesothelioma


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mesothelioma

A neoplasm of serosal surfaces (pleura, peritoneum, pericardium, tunica vaginalis, scrotum) seen in 5–10% of those occupationally exposed to asbestos—especially crocidolite and amosite fibres—with a latency period of 20–40 years. The incidence of mesothelioma increases exponentially if the patient is also a smoker.

Mortality
Up to 10% of workers heavily exposed to asbestos die from mesothelioma.

Butchart staging of pleural mesothelioma
I—Tumour confined to ipsilateral pleura and lung.
II—Tumour involving contralateral pleura, chest wall, mediastinum, pericardium.
III—Tumour involving both the thorax and abdomen or extrathoracic lymph nodes.
IV—Distant blood-borne metastases.
 
Proposed TNM staging
Primary tumour:
• T1—Limited to ipsilateral pleura only;
• T2—Superficial local invasion;
• T3—Deep local invasion;
• T4—Extensive direct invasion.
Lymph nodes:
• N0—No positive lymph node;
• N1—Positive ipsilateral hilar LN;
• N2—Positive mediastinal LN;
• N3—Positive contralateral hilar LN.
Metastases:
• M0—No metastases;
• Ml—Blood-borne or lymphatic metastases.

malignant mesothelioma

Mesothelioma, see there.
References in periodicals archive ?
Hassan, "Chemotherapy and targeted therapies for unresectable malignant mesothelioma," Lung Cancer, vol.
Hyaluronan and N-ERC/mesothelin as key biomarkers in a specific two-step model to predict pleural malignant mesothelioma. PloS One 2013; 8: e72030.
The global malignant mesothelioma market is expected to incur favourable boost from increased healthcare spending witnessed in multiple parts of the world, coupled with availability of better treatment prognosis for mesothelioma.
During 1999-2015, a total of 45,221 deaths with malignant mesothelioma mentioned on the death certificate as the underlying or contributing cause of death among persons aged [greater than or equal to] 25 years were reported in the United States; 16,914 (37.4%) occurred among persons aged 75-84 years, 36,093 (79.8%) occurred among males, 42,778 (94.6%) among whites, and 43,316 (95.8%) among non-Hispanics (Table 1).
[7] Malignant mesothelioma risk factors, http://www.cancer.org/ cancer/malignantmesothelioma/detailedguide/malignant-mesothelioma-risk-factors.
Pei et al., "Germline BAP1 mutations predispose to malignant mesothelioma," Nature Genetics, vol.
The lymphatic drainage system of the pleura is complex and is important in the assessment of the spread of malignant mesothelioma. The visceral pleura drains to the same nodal groups as the lung parenchyma: bronchopulmonary, hilar, mediastinal, supraclavicular, and scalene.
Current approach to malignant mesothelioma of the pleura.
"As we would like to explain to a Veteran or person with malignant mesothelioma who calls us anytime at 800-714-0303, if you want to get the best possible mesothelioma compensation you need very skilled and determined lawyers who know what they are doing." http://MesotheliomaVictimsCenter.Com
[USPRwire, Wed Jan 27 2016] Global Markets Direct's, 'Malignant Mesothelioma - Pipeline Review, H2 2015', provides an overview of the Malignant Mesothelioma's therapeutic pipeline.
Cytokeratin and Calretinin staining were strongly positive in tumor cells, consistent with primary malignant mesothelioma. Subtotal pericardiectomy was performed.

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