malignant mesothelioma


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mesothelioma

A neoplasm of serosal surfaces (pleura, peritoneum, pericardium, tunica vaginalis, scrotum) seen in 5–10% of those occupationally exposed to asbestos—especially crocidolite and amosite fibres—with a latency period of 20–40 years. The incidence of mesothelioma increases exponentially if the patient is also a smoker.

Mortality
Up to 10% of workers heavily exposed to asbestos die from mesothelioma.

Butchart staging of pleural mesothelioma
I—Tumour confined to ipsilateral pleura and lung.
II—Tumour involving contralateral pleura, chest wall, mediastinum, pericardium.
III—Tumour involving both the thorax and abdomen or extrathoracic lymph nodes.
IV—Distant blood-borne metastases.
 
Proposed TNM staging
Primary tumour:
• T1—Limited to ipsilateral pleura only;
• T2—Superficial local invasion;
• T3—Deep local invasion;
• T4—Extensive direct invasion.
Lymph nodes:
• N0—No positive lymph node;
• N1—Positive ipsilateral hilar LN;
• N2—Positive mediastinal LN;
• N3—Positive contralateral hilar LN.
Metastases:
• M0—No metastases;
• Ml—Blood-borne or lymphatic metastases.

malignant mesothelioma

Mesothelioma, see there.
References in periodicals archive ?
The report observes that increasing use of asbestos for commercial purposes is fuelling the incidence of malignant mesothelioma among people.
During 1999-2015, the annual number of malignant mesothelioma deaths increased 4.
There are a number of histologic patterns of malignant mesothelioma that are important, primarily because of diagnostic confusion.
A review of the Malignant Mesothelioma products under development by companies and universities/research institutes based on information derived from company and industry-specific sources
Klebe, "Challenges and controversies in the diagnosis of malignant mesothelioma--part 2: malignant mesothelioma subtypes, pleural synovial sarcoma, molecular and prognostic aspects of mesothelioma, BAP1, aquaporin-1 and microRNA," Journal of Clinical Pathology, vol.
Read, "Primary pericardial malignant mesothelioma and response to radiation therapy," Rare Tumors, vol.
Individual cases of ALT/WDL, myxoid liposarcoma, malignant fibrous histiocytoma, and malignant mesothelioma were also noted.
Germline BAP1 mutations predispose to malignant mesothelioma.
These features suggest the diagnosis of sarcomatoid (fibrous) type malignant mesothelioma.
KEY WORDS: Asbestos Malignant Mesothelioma Peritoneum Surgery.
A post mortem report confirmed he died from malignant mesothelioma due to asbestos exposure.
2] In general, three main histological types of malignant mesothelioma have been described: the epithelial type, the sarcomatous type and the biphasic type.

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