malignant mesothelioma


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mesothelioma

A neoplasm of serosal surfaces (pleura, peritoneum, pericardium, tunica vaginalis, scrotum) seen in 5–10% of those occupationally exposed to asbestos—especially crocidolite and amosite fibres—with a latency period of 20–40 years. The incidence of mesothelioma increases exponentially if the patient is also a smoker.

Mortality
Up to 10% of workers heavily exposed to asbestos die from mesothelioma.

Butchart staging of pleural mesothelioma
I—Tumour confined to ipsilateral pleura and lung.
II—Tumour involving contralateral pleura, chest wall, mediastinum, pericardium.
III—Tumour involving both the thorax and abdomen or extrathoracic lymph nodes.
IV—Distant blood-borne metastases.
 
Proposed TNM staging
Primary tumour:
• T1—Limited to ipsilateral pleura only;
• T2—Superficial local invasion;
• T3—Deep local invasion;
• T4—Extensive direct invasion.
Lymph nodes:
• N0—No positive lymph node;
• N1—Positive ipsilateral hilar LN;
• N2—Positive mediastinal LN;
• N3—Positive contralateral hilar LN.
Metastases:
• M0—No metastases;
• Ml—Blood-borne or lymphatic metastases.

malignant mesothelioma

Mesothelioma, see there.
References in periodicals archive ?
The ODD for amatuximab highlights the need for new effective treatments for people with malignant mesothelioma and the potential for this investigational drug," says Gary Hendler, President & CEO Eisai EMEA & Russia.
Gene expression profiling of malignant mesothelioma.
This pattern of immunostaining with clinicohistopathologic findings was diagnostic of malignant mesothelioma (Table 2).
After a biopsy which confirmed the diagnosis of malignant mesothelioma, he was told that no treatment was available.
The morphological and immunohistochemical profile is congruent with the diagnosis of a malignant mesothelioma (Figure 3).
The worldwide incidence of malignant mesothelioma is on the rise and is not expected to peak for another 10 to 20 years.
Until recently, histochemical stains and electron microscopy were the standard tools used for the diagnosis of malignant mesothelioma.
Malignant mesothelioma (MME) is an aggressive tumor of serosal surfaces resistant to current treatment options.
Thomas Lennon died of pressure on the sack around the heart due to malignant mesothelioma on April 23.
Every year, almost 2,000 people are diagnosed with diffuse or malignant mesothelioma in the UK and although the majority of cases affect the lung, a small number affect the stomach.
ONCONASE was previously granted orphan drug status as well as fast-track development status by the United States Food and Drug Administration (FDA) for the treatment of malignant mesothelioma.

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