malignant meningioma


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ma·lig·nant me·nin·gi·o·ma

meningioma that is poorly differentiated, has excessive mitotic activity, or metastasizes.

malignant meningioma

A rare, aggressive meningeal tumour of brain and spinal cord.
 
Clinical findings
Headaches, new onset seizures, focal weakness, mental changes, unusual behaviour, urinary incontinence, anosmia, cranial nerve defects, decreased vision, contralateral hemianopsia, hearing loss, spinal pain.

Management
Medical management is useless; some meningiomas have increased fatty acid synthesis, which might provide a therapeutic handle in the distant future; surgery is indicated for meningiomas likely to continue growing (tumours with greatest growth potential lack calcification, are hyperintense in T2 by MRI, and have peritumoral oedema).

Prognosis
65% 5-year survival; 35% 10-year survival.
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References in periodicals archive ?
Table-I: Diagnostic accuracy of DWI with Histopathology as Gold Standard to differentiate benign and Malignant Meningiomas (n= 152).
One hundred and fifty two patients were enrolled to determine the diagnostic accuracy of Diffusion Weighted MRI in differentiating benign and malignant meningiomas keeping histopathology as gold standard.There were 59 males and 93 females, aged from 21 to 70 years with mean age of 55.38 +- 9.8 years.
For the surgical and treatment planning a diagnostic method is highly desirable for accurate distinction between benign and malignant meningiomas.12 Diffusion weighted imaging (DWI) along with the calculation of apparent diffusion coefficient (ADC), is a reliable and non-invasive technique of choice for accurate assessment and in treatment planning of different types of brain tumors.
Lobrinus, "Primary pulmonary malignant meningioma with lymph node and liver metastasis in a centenary woman, an autopsy case," Virchows Archiv, vol.
The more aggressive varieties, the so-called 'atypical' and malignant meningiomas, present their own specific problems for treatment.
Asim Mohmmed, Dariou Cecum, Frank J, Tomeck, Ghansi A typical and malignant meningiomas, A clinicopathological Review.
"Age and gender characteristics of the growth of malignant meningiomas of brain and spinal cord during the period of 1999-2007 years," Abstracts of the All-Russian scientific-practical conference "Polenovskie chteniya" [Materiali Vse-Rossiyskoy nauchno-prakticheskoy konferencii "Polenovskie chteniya"], in Russian, St.
"Intracranial complications of surgical treatment for brain malignant meningiomas," Abstracts of the All-Russian scientific-practical conference "Polenovskie chteniya" [Materiali Vse-Rossiyskoy nauchno-prakticheskoy konferencii "Polenovskie chteniya"], in Russian, St.
Adjuvant radiotherapy for atypical and malignant meningiomas: A systematic review.
(28) immunohistochemically examined 69 meningiomas and found p53 protein expression in 57% of cases, with higher levels in atypical and malignant meningiomas compared to benign tumors.

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