malignant fibrous histiocytoma


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ma·lig·nant fi·brous his·ti·o·cy·to·ma

a sarcoma of variable malignant potential, occurring most often in the extremities and retroperitoneum; often recurs locally after resection, less often metastasizes; shows partial fibroblastic and histiocytic differentiation with a variable storiform pattern, myxoid areas, and giant cells.

malignant fibrous histiocytoma

A malignant tumour consisting of mitotically active spindled cells arranged in a storiform pattern. Malignant fibrous histiocytoma is no longer considered an entity a sui generis, given that many MFHs proved to be melanomas, poorly-differentiated carcinomas and lymphomas when examined by immunohistochemistry.

Reclassification of MFH types
• Angiomatoid type malignant fibrous histiocytoma—now Angiomatoid fibrous histiocytoma.
• Inflammatory malignant fibrous histiocytoma—now Inflammatory de-differentiated liposarcoma.
• Giant cell malignant fibrous histiocytoma, high grade—now Giant cell-rich extraskeletal osteosarcoma.
• Giant cell malignant fibrous histiocytoma, low grade—now Giant cell tumour of soft tissue.
• Malignant fibrous histiocytoma, myxoid type—now Myxofibrosarcoma.

malignant fibrous histiocytoma

A pleomorphic mesenchymal malignancy of older adults, which affects deep soft tissues–involving muscle 60% or fascia 20% of the lower–50% and upper–20% extremities, retroperitoneum 15% and abdominal cavity; MFH metastasizes to the lung 80%, lymph nodes 30%, liver, bone DiffDx Sarcomas, pleomorphic or primitive carcinoma, bizarre melanoma Prognosis 40-65% of tumors recur; 25-50% metastasize

ma·lig·nant fi·brous his·ti·o·cy·to·ma

(mă-lig'nănt fī'brŭs his'tē-ō-sī-tō'mă)
A deeply situated tumor, especially on the extremities of adults, frequently recurring after surgery and metastasizing to the lungs; shows partial fibroblastic and histiocytic differentiation with a variable storiform pattern, myxoid areas, and giant cells.
References in periodicals archive ?
Moriyama, "Primary malignant fibrous histiocytoma of the chest wall: CT and MR appearance," Journal of Computer Assisted Tomography, vol.
Treatment of malignant fibrous histiocytoma, like other tumors, is chemotherapy and preferably excision, if possible.
A recent study [13] reported the case of a 37-year-old male patient who received external radiotherapy for a malignant fibrous histiocytoma. The patient was offered a postoperative RT because of inadequate surgical margins.
Dai, "Clinical characteristics of the primary hepatic malignant fibrous histiocytoma in China: Case report and review of the literature," World Journal of Surgical Oncology, vol.
Primary malignant fibrous histiocytoma of the spleen: recurrence eight years after splenectomy: report of a case and literature review.
Malignant fibrous histiocytoma demonstrate low signals on T1WI and high signals on T2WI with postcontrast enhancement.
Primary hepatic malignant fibrous histiocytoma of the kidney: report of a case.
Malignant fibrous histiocytoma, pleomorphic, recurrence, radical excision, radiation therapy.
The clinical differential diagnosis includes ranula, dermoid cyst, thyroglossal duct cyst, ectopic thyroid tissue, pleomorphic adenoma and mucoepidermoid carcinoma, angiolipoma, fibrolipoma and malignant lymphoma.9-11 A histopathologic differential diagnosis appropriate to the oral cavity would include fibrosarcoma if spindle cells are not localized and numerous.12 Other lesions should be also considered: they include schwanoma, myxoidneurofibroma, leiomyoma, nodular fasciitis, myxolipoma, fibrolipoma, malignant fibrous histiocytoma, myxoidliposarcoma, and myxoid solitary fibrous tumor.
This case represents a very rare example of CS/SC of the urinary bladder with a malignant fibrous histiocytoma component that was characterized by morphologic and immunohistochemical findings, and proves that CS/SC of the urinary bladder is a very aggressive neoplasm.

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