malignant ascites

malignant ascites

Excess peritoneal fluid evoked by malignancy, which causes subdiaphragmatic lymphatic obstruction (e.g., of the thoracic duct) and increased intraperitoneal fluid production.

Clinical findings
Abdominal distension, weight gain, indigestion, dyspnea, orthopnea, tachypnoea, intestinal obstruction with nausea, vomiting.
 
Aetiology
Ovarian, breast, gastric, pancreatic, hepatic, and colorectal carcinomas, lymphoma, mesothelioma.
 
DiffDx
Tuberculosis, congestive heart failure, nephrotic syndrome, hepatic disease, bacterial peritonitis, malnutrition (due to hypoalbuminemia).
 
Management
Drainage of fluid, intraperitoneal chemotherapy, antibiotics, radioactive colloids, biological response modifiers (e.g., IL-2, alpha-IFN, external-beam radiation therapy), and surgical placement of LeVeen or Denver shunts.
 
Prognosis
Poor.

malignant ascites

Excess peritoneal fluid evoked by malignancy, which causes subdiaphragmatic lymphatic obstruction–eg, of the thoracic duct and ↑ intraperitoneal fluid production Etiology Ovarian, breast, gastric, pancreatic, hepatic, colorectal CA, lymphoma, mesothelioma Clinical Abdominal distension, weight gain, indigestion, dyspnea, orthopnea, tachypnea, intestinal obstruction with N&V Imaging Ground glass appearance, central positioning of small bowel loops, and obscured psoas sign on plain abdominal films; MA is confirmed with ultrasonography, CT, and MRI DiffDx TB, CHF, nephrotic syndrome, hepatic disease, bacterial peritonitis, malnutrition–due to hypoalbuminemia Management Drainage of fluid; intraperitoneal chemotherapy, antibiotics, radioactive colloids, biological response modifiers–eg, IL-2, α-IFN, external-beam RT, and surgical placement of LeVeen or Denver shunts Prognosis Poor
References in periodicals archive ?
In postmenopausal women, a gynecologic (especially ovarian) primary should be considered as a major differential diagnostic consideration in the setting of malignant ascites and/or pleural effusion.
These presentations vary widely, with most patients presenting with new-onset malignant ascites. We report our experience of two cases presenting within a decade with peritoneal carcinomatosis following robotic-assisted laparoscopic radical prostatectomy for prostate cancer.
A phase I clinical trial for malignant ascites is planned to initiate in China this year.
[6-9] It was observed that the mean ascitic fluid LDH level was much lower in patients with liver diseases than in those with malignant ascites (167 [+ or -] 9 vs 913 [+ or -] 228 SU).
(2) Malignant ascites is present in up to a quarter of patients.
Metastatic prostate cancer with malignant ascites: A case report and literature review.
(1) Malignant ascites, representing 10% to 15% of all cases, results from altered vascular permeability in primary abdominal or peritoneal metastatic cancers.
The 61-year-old, from Prestatyn, secured funding from Betsi Cadwaladr University Health Board for permanent drains, which are now inserted into women in the palliative care stage of their disease, who develop malignant ascites which cause a painful build up of fluid in the stomach.
Malignant peritoneal effusion (MPeE) is a marker that frequently indicates advanced malignant disease, and malignant ascites is a grave prognostic sign.
of Denville, N.J., won for its blow-molded 1,000ml PleurX Drainage Bottle (right), which automatically helps patients to safely and efficiently drain fluid buildup from recurrent pleural effusions and malignant ascites at home in only 5 to 15 minutes without the need for gravity.
Value of ascitic lipids in the differentiation between cirrhotic and malignant ascites. Hepatology 1986; 6: 239-243.
The cancer had triggered malignant ascites, a buildup of fluid in the abdomen.