malic enzyme


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ma·late de·hy·dro·gen·ase (MD),

an enzyme that, using either NAD+ or NADP+, catalyzes the dehydrogenation of malate to oxaloacetate or its decarboxylation to pyruvate and CO2. At least six malate dehydrogenases are known, distinguished by their products, use of NAD+ or NADP+, and specificity of substrate (one acts on d-malate, the rest act on l-malate); one of these proteins is an enzyme in the tricarboxylic acid cycle.

malic enzyme

(1) Malate dehydrogenase (oxaloacetate-decarboxylating), EC 1.1.1.38.
(2) Malate dehydrogenase (decarboxylating), EC 1.1.1.39.
(3) Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+), EC 1.1.1.40.
References in periodicals archive ?
Differences between mouse and rat pancreatic islets: Succinate responsiveness, malic enzyme, and anaplerosis.
Aberrant chloroplasts in transgenic rice plants expressing a high level of maize NADP-dependent malic enzyme. Planta, 211: 265-274
Hormonal regulation of malic enzyme and glucose-6-phosphate dehydrogenase in brown adipose tissue.
The activities of lactate dehydrogenase (LDH) fatty acid synthase (FAS) malic enzyme (ME) and glucose-6-phosphate dehydrogenase (G6-PDH) were determined in the LM of pigs.
Second, glucose stimulates the lipogenic enzyme synthesis of ATP-citrate lyase, G6PDH, ACC, malic enzyme, and FAS (8).
Ratledge, "The role of malic enzyme in the regulation of lipid accumulation in filamentous fungi," Microbiology, vol.
Effects of methotrexate (MTX) on NAD(P)+ dehydrogenases of HeLa cells: malic enzymes, 2-oxoluterate and isocitrate dehydrogenases.
Using this method, activities of enzymes: glucose-6-phosphate dehydrogenase (G6PDG, malic enzyme (NADPMDG), NAD- and NADH-dependent lactate dehydrogenase (LDG and NADH-LDG), NAD- and NADH-dependent malate dehydrogenase (MDG and NADH-MDG), NADP- and NADPH-dependent glutamate dehydrogenase (NADP-GDG and NADPHGDG), NAD- and NADH-dependent glutamate dehydrogenase (NAD-GDG and NADH-GDG), NAD and NAD-dependent isocitrate dehydrogenase (NADICDG and NADP-ICDG), and glutathione reductase (GR) were studied.
Based on the results of our study, essential erythroid proteins (ankyrin recurrent and FYVE bundle containing protein 1, spectrin alpha, actin-depolymerization factor, actin-depolymerizing factor, LIM bundle and actin binding subunit 1 isoform a, LIM bundle and actin binding subunit 1 isoform b, NADP-dependent malic enzyme, NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, mitochondrial NADP (+) dependent malic enzyme 3, ribulose bisphosphate-carboxylase large chain, maturase K) and the required ATP bioenergy (ATP synthase, ATP synthase beta subunit, ATP synthase alpha subunit, ATP-binding protein C12, TP synthase H+ transporter protein, ADF, and alpha-1,2-glycosyltransferase ALG10-A) are included in the protein library of Ankaferd.
This result might also be due to the low respiration activity of these fruits, since low respiration activity reduced the consumption of malic acid by the activity of the malic enzyme in the tricarboxylic acid cycle (GOODENOUGH et al., 1985).