malate-aspartate shuttle


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Related to malate-aspartate shuttle: glycerophosphate shuttle, Glycerol phosphate shuttle

mal·ate-as·par·tate shut·tle

a mechanism for the transfer of NADH, reducing equivalents from the cytosol into the mitochondria using two isozymes of malate dehydrogenase and aspartate aminotransferase.
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Since the polyol pathway generates NADH that can be fed into complex I via the malate-aspartate shuttle, we would like to discuss the role of this pathway in diabetes in a little more detail.