malate dehydrogenase

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ma·late de·hy·dro·gen·ase (MD),

an enzyme that, using either NAD+ or NADP+, catalyzes the dehydrogenation of malate to oxaloacetate or its decarboxylation to pyruvate and CO2. At least six malate dehydrogenases are known, distinguished by their products, use of NAD+ or NADP+, and specificity of substrate (one acts on d-malate, the rest act on l-malate); one of these proteins is an enzyme in the tricarboxylic acid cycle.
Farlex Partner Medical Dictionary © Farlex 2012

malate dehydrogenase

An oxidoreductase (EC in mitochondria and the cytosol that catalyses the reversible NAD+/NADH reaction in the presence of S-malate, yielding oxaloacetate, a step in the citric acid cycle. Malate dehydrogenase is increased in myocardial infarction, hepatocellular necrosis, megaloblastic anaemia, and cancer.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

mal·ate de·hy·dro·gen·ase

(mal'āt dē-hī'drō-jĕ-nās)
Any enzyme that catalyzes the dehydrogenation of malate to oxaloacetate. At least six are known; one is an enzyme in the tricarboxylic acid cycle.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
The gels were stained for esterase (EST) as per the procedure of Glaszmann (1987), acid phosphatase (ACP) Vallejos (1983), alcohol dehydrogenase (ADH) and malate dehydrogenase (MDH) Shaw and Prasad (1970).
Malate dehydrogenase, pyruvate kinase, and glucose-6-phosphate dehydrogenase activities were not affected significantly by dietary CBH levels.
Malate dehydrogenase (MDH), a key enzyme in the tricarboxylic acid cycle (TCA), plays important metabolic roles in aerobic energy producing pathways and in malate shuttle (Figure 1) [5].
1.9), Glycerol-3-phosphate dehydrogenase (G3PDH, EC, Isocitrate dehydrogenase (IDH, EC, L-lactate dehydrogenase (LDH, EC, Malate dehydrogenase (MDH, EC 1.1.
Of the enzyme systems initially assayed, alcohol dehydrogenase (ADH); lactate dehydrogenase (LDH); malate dehydrogenase (MDH); phosphohexose isomerase (PHI/PGI); and 6-phosphogluconate dehydrogenase (6-PGD) resolved consistently.
The tested enzymes were aconitase (ACO), acid phosphatase (ACP), alcohol dehydrogenase (ADH), adenylate kinase (AK), arginine aminopeptidase (AMP), diaphorase (DIA), endopetidase (EP), esterase (EST), fructose-1,6-diphosphatase (FDP), glutamate dehydrogenase (GDH), glutamate oxaloacetate transaminase (GOT), hexokinase (HK), isocitrate dehydrogenase (ICD), leucine aminopeptidase (LAP), malate dehydrogenase (MDH), malic enzyme (ME), peptidase with leucyl-alanine (PEP-LA), 6-phosphogluconate dehydrogenase (PGD), phosphoglucoisomerase (GPI), and shikimate dehydrogenase (SKDH) (Siciliano and Shaw, 1976; Vallejos, 1983; Van Geyt and Smed, 1984; Acquaah, 1992).
We scored nucleoside phosphorylase (Nsp), adenosine deaminase (Ada), and 6-phosphogluconate dehydrogenase (6-Pgd) on tris malate (pH 7.4); phosphoglucomutase (Pgm-1&2), tripeptide aminopeptidase (Pep-A&B), and malic enzyme (Mod) on tris citrate (pH 8.0); and lactate dehydrogenase (Ldh-1&2), glucose-6-phosphate isomerase (Gpi), and malate dehydrogenase (Mdh-1&2) on amine citrate (pH 6.1).
Bands were revealed for the enzyme systems esterase (EST), according to Scandalios (1969), alcohol dehydrogenase (ADH), phosphoglucose isomerase (PGI), malate dehydrogenase (MDH) and malic enzyme (ME), described by Alfenas (1991), and alpha amylase ([alpha] - AMY), according to Alfenas (1998).