malaria parasite


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Related to malaria parasite: Plasmodium falciparum

malaria parasite

the PROTOZOAN Plasmodium that causes malaria in man. It is transmitted by the Anopheles mosquito which takes in Plasmodium GAMETOCYTES when feeding on man. The gametocytes develop into male and female gametes in the mosquito stomach, and after fertilization the ZYGOTE bores through the stomach wall, encysts, and gives rise to thousands of sporozoites which then migrate to the salivary glands. The sporozoites are transferred to man at a subsequent blood meal during which anticoagulants are injected with the saliva to prevent blood clotting.

Sporozoites invade the human liver and give rise to merozoites that invade red blood corpuscles. Further production of merozoites occurs in the red blood corpuscle and their release into the blood stream gives rise to bouts of fever (‘malaria’). Gametocytes arise from merozoites which invade further red blood corpuscles, grow within them, and are withdrawn by the mosquito during feeding, to complete the life cycle.

References in periodicals archive ?
These countries have warmer climates that are hot enough for the malaria parasites and the mosquitoes that carry them to thrive.
The study published in the journal of Proceedings of the National Academy of Sciences showed how the mosquito immune system combats malaria parasites at multiple stages of development.
But when they found that the compounds they were testing also affected the malaria parasites inside the mosquitos, they shifted their focus.
In a study publishing December 7 in Science, Winzeler and her team took a different approach: targeting the malaria parasite at an earlier stage in its lifecycle, when it initially infects the human liver, rather than waiting until the parasite is replicating in blood and making a person ill.
Sniffer dogs could provide a noninvasive, portable and rapid test for identifying malaria carriers and would be particularly useful in settings where there are few individuals with malaria parasites.
"Existing malaria medicines are becoming less effective because of the rise in drug resistance in malaria parasites," said Sandra Shotwell, Ph.D., DesignMedix co-founder and CEO.
Origin of the human malaria parasite Plasmodium falciparum in gorillas.
After being transferred into a new host via a mosquito bite, malaria parasites work their way into the liver, where they mature and reproduce.
It was also evident that geohelminths and malaria parasite coinfections were associated with various adverse birth outcomes.
The current approaches to malaria elimination by the World Health Organization (WHO) have been fueled by the GMEP, which can crown a country to have achieved malaria elimination when there is reduction to zero of the incidence of infection caused by a specified malaria parasite in a defined geographical area as a result of deliberate efforts [66].
Sanaria Inc, a company that develops and commercialises whole-parasite malaria vaccines, announced on Monday that a clinical trial of Sanaria PfSPZ (Plasmodium falciparum sporozoite) Vaccine to prevent malaria infections has shown that the vaccine provided protection against infection with malaria parasites for at least 14 months in subjects who were exposed to Plasmodium falciparum parasites, the malaria parasite that causes about 438,000 deaths and 214 million cases each year.
The white-tailed deer, maybe the best-studied wild animal in North America, carries a malaria parasite that science has overlooked for decades.