The total energy fluctued between -3904 eV and -2054 eV, values related to malaoxon
and acephate respectively.
Dominica were less sensitive to malaoxon
inhibition than the susceptible populations.
Specifically, for Volume 112, the analyses included 7 chemicals: 3 of the 5 agents evaluated (diazinon, malathion and parathion), one isomer (of tetrachlorvinphos) and three metabolites (diazoxon, malaoxon
Younglove, Assessment of Malathion and Malaoxon
Concentration and Persistence in Water, Sand, Soil and Plant Matrices Under Controlled Exposure Conditions, Environmental Hazards Assessment Program State Of California Environmental Protection Agency Department of Pesticide Regulation, 1993.
Under the optimized experimental conditions, wide linear concentration ranges and very low detectability levels were obtained for the chronoamperometric identification of aldicarb, carbofuran, malaoxon
, and methyl-paraoxon, as can be seen from data shown in Table 3.
Both malathion and malaoxon
are rapidly metabolized and their toxicity reduced with this enzyme system.
Other studies describe the possibility of malaoxon
to induce DNA breaks where the tumor suppressor genes are located so this metabolite of Malathion could be, considered as a potential carcinogen and mutagen, .
If this threshold was further decreased to 60%, an additional 3 chemicals would be selected, leaving only malaoxon
(56% similarity with mevinphos) unidentified from our analysis.
From the assay evaluation, the final purified ChE procedure displayed the highest sensitivity of detecting the anticholinesterase namely mercury, copper, malaoxon
and carbofuran compared to the impure ChE and the results were further discussed in detail to the potential application of ChE from P.
La toxicidad del malathion se debe a sus metabolitos, el malaoxon
e isomalathion, que son 40 veces mas toxicos que el malathion.
The toxic effects of malathion are related to its CYP-mediated oxidative desulfuration to bioactive malaoxon
leading to accretion of acetylcholine in neuroeffector junctions.
Malathion and malaoxon
PESTANAL analytical standards were purchased from Sigma-Aldrich (St Louis, MO).