malaoxon


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malaoxon

An anticholinesterase organophosphate phosphorothioate used against insects (e.g., aphids, spiders, mites, houseflies). It is a breakdown product of malathion and even more toxic.

Clinical findings
Miosis, frontal headache, bronchial hypersecretion, nausea, vomiting, sweating, abdominal cramps, diarrhoea, lacrimation, drooling, bradycardia, cyanosis, and twitching of the eyelids, tongue, face and neck, progressing to convulsions, hypotension and respiratory failure.

malaoxon

Toxicology An anticholinesterase organophosphate used against insects–aphids, spiders, mites, houseflies, and other creepy crawlies. See Intermediate syndrome, Organophosphate pesticide.
References in periodicals archive ?
The total energy fluctued between -3904 eV and -2054 eV, values related to malaoxon and acephate respectively.
Specifically, for Volume 112, the analyses included 7 chemicals: 3 of the 5 agents evaluated (diazinon, malathion and parathion), one isomer (of tetrachlorvinphos) and three metabolites (diazoxon, malaoxon and paraoxon).
Younglove, Assessment of Malathion and Malaoxon Concentration and Persistence in Water, Sand, Soil and Plant Matrices Under Controlled Exposure Conditions, Environmental Hazards Assessment Program State Of California Environmental Protection Agency Department of Pesticide Regulation, 1993.
Under the optimized experimental conditions, wide linear concentration ranges and very low detectability levels were obtained for the chronoamperometric identification of aldicarb, carbofuran, malaoxon, and methyl-paraoxon, as can be seen from data shown in Table 3.
Both malathion and malaoxon are rapidly metabolized and their toxicity reduced with this enzyme system.
Other studies describe the possibility of malaoxon to induce DNA breaks where the tumor suppressor genes are located so this metabolite of Malathion could be, considered as a potential carcinogen and mutagen, [8].
If this threshold was further decreased to 60%, an additional 3 chemicals would be selected, leaving only malaoxon (56% similarity with mevinphos) unidentified from our analysis.
From the assay evaluation, the final purified ChE procedure displayed the highest sensitivity of detecting the anticholinesterase namely mercury, copper, malaoxon and carbofuran compared to the impure ChE and the results were further discussed in detail to the potential application of ChE from P.
The toxic effects of malathion are related to its CYP-mediated oxidative desulfuration to bioactive malaoxon leading to accretion of acetylcholine in neuroeffector junctions.
Malathion and malaoxon PESTANAL analytical standards were purchased from Sigma-Aldrich (St Louis, MO).