Makorin ring finger protein 1 | definition of makorin ring finger protein 1 by Medical dictionary

https://medical-dictionary.thefreedictionary.com/makorin+ring+finger+protein+1

Dictionary, Encyclopedia and Thesaurus - The Free Dictionary 12,596,249,598 visitors served

Search / Page tools

A
A
A
A

Language:

Get our app

9

Register

Get
our app

makorin ring finger protein 1

An E3 ubiquitin ligase encoded by MKRN1 on chromosome 7q34, which catalyses the covalent attachment of ubiquitin moieties onto substrate proteins FILIP1, p53/TP53, CDKN1A and TERT. Makorin ring finger protein 1 keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress. It downregulates telomerase and up- and downregulates RNA polymerase II-dependent transcription.

Full browser ?

CITE

Site: Follow: Share:

Open / Close