Major salivary glands
include submandibular and parotid glands (Dursun, 1999; International Committee on Veterinary Gross Anatomical Nomenclature, 2012).
In rats, TGF-[alpha] expression has been reported in all three major salivary glands
and is found throughout the entire ductal system excluding the acinar cells (Wu et al., 1993).
The mucous retention phenomena are true cysts which have an epithelial lining are found in older age group and in this category the major salivary glands
are involved.4 Oral mucocele is dome -shaped enlargements with epithelium intact.5 The clinical presentation with respect to size, site, aetiology, appearance and symptoms is very important because it can differentiate the benign from the premalignant benign lesions,Confirmation by histopathology and excision surgically are important and necessary.6
The ICCR salivary glands cancer data set is specific to resection specimens and some biopsies of malignant neoplasms and associated carcinoma in situ arising from the major salivary glands
. (52) Melanomas, lymphomas, and sarcomas are dealt with in separate data sets.
 Sialoliths are calcified organic matters that form within the secretory system of the major salivary glands
. The sialoadenitis do occur whenever there is reduced salivary flow which results into retrograde infection of the glandular tissue via the salivary duct.
The 'Adenoid Cystic Carcinoma' (ACC) is a tumor of exocrine glands originating primarily from the minor salivary glands of the upper respiratory gland, the major salivary glands
, lacrimal gland, bronchus, breast, and intestinal and genital tracts. Its key characteristic is that it grows slowly; however, peritumoral invasion and perineural infiltration occur in the process.
Saliva which is major secretion in the oral cavity of most vertebrates is produced by three pairs of major salivary glands
(parotid, submandibular, sublingual) and approximately 600-1000 minor salivary glands located within labial, buccal, lingual mucosa.
Salivary gland carcinoma is rare entity, accounting for up to 6% of head and neck cancers, with the parotid gland being the most frequent site among the major salivary glands
Garrett, "Lipid accumulation in the major salivary glands
of streptozotocin-diabetic rats," Archives of Oral Biology, vol.
Unlike other benign salivary masses, WT has unique behavior in that it may occur bilaterally and outside of the major salivary glands
. The pathogenesis of "extra-parotid" WT remains controversial.
Basal cell adenocarcinomas of the major salivary glands
. Oral Surg Oral Med Oral Pathol 1990; 69: 461-9.
(10,14-16) In veterinary medicine, spontaneous mucoepidermoid carcinomas have been reported in dogs and cats, an African lion (Panthera leo), and an African hedgehog (Atelerix albiventris), most commonly affecting the major salivary glands
. (13,17-19) Mucoepidermoid carcinoma has been reported as a rare occurrence in birds.