major basic protein


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major basic protein

a cytotoxic and proinflammatory mediator found in eosinophil granules.

major basic protein

An 11-kD major cytotoxic and helminthotoxic protein encoded by PRG2 on chromosome 11q12, which forms a characteristic crystalloid and is found in the granules of eosinophils and other myeloid cells. It induces non-cytolytic histamine release from human basophil, and is involved in antiparasitic defence and immune hypersensitivity reactions.

The adjectival “basic” derives from MBP’s isoelectric point of greater than pH 10. MBP is capable of killing parasites, as well as host cells; it causes bronchial epithelial damage and a wheal and flare response when injected subcutaneously, and it has been linked to asthma.
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Pregnancy-associated plasma protein A and its endogenous inhibitor, the proform of eosinophil major basic protein (proMBP), are related to complexstenosis morphology in patients with stable angina pectoris.
Inhibition of proteolysis by the proform of eosinophil major basic protein (proMBP) requires covalent binding to its target proteinase.
Isolation and characterization of circulating complex between human pregnancy-associated plasma protein-A and proform of eosinophil major basic protein.
Double-monoclonal immunofluorometric assays for pregnancy-associated plasma protein A/proeosinophil major basic protein (PAPP-A/proMBP) complex in first-trimester maternal serum screening for Down syndrome.
Proteinase inhibition by proform of eosinophil major basic protein (proMBP) is a multistep process of intra- and intermolecular disulfide rearrangements.
Covalent interaction between proform of eosinophil major basic protein (proMBP) and pregnancy-associated plasma protein-A (PAPP-A) is a cell-mediated event and required for proMBP inhibition of the catalytic activity of PAPP-A.
Cloning and sequence analysis of the human gene encoding eosinophil major basic protein.
Regulation and processing of a precursor form of eosinophil granule major basic protein (ProMBP) in differentiating eosinophils.
Acidic precursor revealed in human eosinophil granule major basic protein cDNA.
Identification of angiotensinogen and complement C3dg as novel proteins binding proform of eosinophil major basic protein in human pregnancy serum and plasma.
Monoclonal antibodies against the complex of human pregnancy-associated plasma protein-A and the proform of eosin ophil major basic protein (PAPP-A/proMBP-complex): production, characterization, epitope analysis and application in immunochemical assays for PAPP-A/proMBP-complex [Abstract].
Location and nature of carbohydrate groups in proform of human major basic protein isolated from pregnancy serum.