major basic protein


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major basic protein

a cytotoxic and proinflammatory mediator found in eosinophil granules.

major basic protein

An 11-kD major cytotoxic and helminthotoxic protein encoded by PRG2 on chromosome 11q12, which forms a characteristic crystalloid and is found in the granules of eosinophils and other myeloid cells. It induces non-cytolytic histamine release from human basophil, and is involved in antiparasitic defence and immune hypersensitivity reactions.

The adjectival “basic” derives from MBP’s isoelectric point of greater than pH 10. MBP is capable of killing parasites, as well as host cells; it causes bronchial epithelial damage and a wheal and flare response when injected subcutaneously, and it has been linked to asthma.
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[5] Nonstandard abbreviations: PAPP-A, pregnancy-associated plasma protein A; ACS, acute coronary syndrome; proMBP, proform of eosinophil major basic protein; FPAPP-A, free form of PAPP-A; TPAPP-A, total PAPP-A; cTnI, cardiac troponin I; ECG, electrocardiogram; CRP, C-reactive protein; FDA, US Food and Drug Administration; RR, risk ratio.
Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissues.
Double-monoclonal immunofluorometric assays for pregnancy-associated plasma protein A/proeosinophil major basic protein (PAPP-A/proMBP) complex in first-trimester maternal serum screening for Down syndrome.
Quantification and characterization of pregnancy-associated complexes of angiotensinogen and the proform of eosinophil major basic protein in serum and amniotic fluid.
Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta.
Acidic precursor revealed in human eosinophil granule major basic protein cDNA.
Expression of eosinophil-granule major basic protein messenger ribonucleic acid in placental X cells.
Elevated serum levels in human pregnancy of a molecule immunochemically similar to eosinophil granule major basic protein. J Exp Med 1983;158:1211-26.
Increases of plasma eosinophil major basic protein levels late in pregnancy predict onset of labor.
The proform of eosinophil major basic protein: a new maternal serum marker for Down syndrome.
Location and nature of carbohydrate groups in proform of human major basic protein isolated from pregnancy serum.
{5} Nonstandard abbreviations: DS, Down syndrome; CVS, chorionic villus sampling; AC, amniocentesis; PAPP-A, pregnancy-associated plasma protein A; proMBP, proeosinophil major basic protein; TrlFMA, time-resolved immunofluorometric assay; SP1, pregnancy-specific glycoprotein 1 (Schwangerschaftsprotein 1); hCG, human chorionic gonadotropin; MoMs, multiples of the medians.