magainin


Also found in: Dictionary, Wikipedia.
Related to magainin: protegrin

magainin

A peptide, originally found in the skin of the African clawed frog, which has antimicrobial activity.

magainin

Any of a family of  peptide antibiotics with antibacterial and antiparasitic activities, originally extracted from the skin of Xenopus laevis (African clawed frog), which have a broad spectrum of antimicrobial activity against bacteria, fungi, protozoa and viruses. A magainin derivative, pexiganan, is in phase-3 trials for diabetic ulcers.
Mentioned in ?
References in periodicals archive ?
Kinetics of pore formation by an antimicrobial peptide, magainin 2, in phospholipid bilayers.
(1987) Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.
2008) and magainins, a class of peptides from the skin of African clawed frog, Xenopus laevis (Edelstein et al.
A silicone rubber surface modified by photochemical immobilization of an antimicrobial peptide, magainin, inhibited the growth of S.
In his team's tests, nisin was 1,000 times as toxic to target bacteria as was magainin, a natural antibiotic produced in animals (SN: 3/18/95, p.
Los cientificos de la empresa de biotecnologia Magainin Pharmaceuticals descubrieron la "squalamina" en 1992, cuando, buscaban sustancias antibioticas," en el higado de una clase de tiburones pequenos.
Lactoferricin has been shown to display a similarity with an antimicrobial peptide, magainin. Both peptides are able to traverse the bacterial cytoplasmic membrane [130].
En esa investigacion, el equipo dirigido por el doctor Nicholas Nicolaides, del Instituto de medicina molecular de la firma Magainin Pharmaceuticals en Plymouth Meeting (Pennsylvania), logro aislar en un raton un gen responsable de la hipersensibilidad de los bronquios, considerada como una de las causas del asma.
Using a synthetic version of the substance found in frogs, Magainin Pharmaceuticals of Plymouth Meeting, Pa., has already begun to make a natural antibiotic intended for the treatment of cystic fibrosis.
Representative analogue of antimicrobial peptides magainin 2 and buforin 2 was found to enter the human carcinoma cells through membrane translocating mechanisms.
In the study by Matanic and Castilla (2004), the in vitro antiviral activity of antimicrobial cationic peptides cecropin A, melittin, magainin I and II, and indolicidin against the arenavirus Junin virus (JV), and herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) was evaluated.
He and his colleagues at Magainin Pharmaceuticals, a company he founded in Plymouth Meeting, Pa., report their finding in the March 17 Science.