However, manual segmentation of macular drusen area and volume is time consuming and labor intensive, which limits its use in large-scale population.
Nagasaki et al., "Automated detection of macular drusen using geometric background leveling and threshold selection," Archives of Ophthalmology, vol.
Fundus examination revealed macular drusen
as well as mild macular whitening and an early cherry red spot (Figure 1(a)).
AMD Alternative Description phenotype name MD1 Pre-AMD Hard macular drusen
(<63 [micro]m) only MD2 Subclinical Soft, distinct macular drusen
pre-AMD (>63 [micro]m) Macular pigmentary irregularities without soft drusen Dry AMD Dry AMD Soft, indistinct (>125 [micro]m) or (non-GA) reticular macular drusen
Soft distinct macular drusen
(>63 [micro]m) with pigmentary changes Soft indistinct macular drusen
with pigmentary changes GA Geographic Sharply demarcated area of apparent atrophy absence of the RPE (>175 [micro]m) involving central macular region CNV Wet AMD Subretinal choroidal neovascularization GA/CNV Geographic atrophy with choroidal neovascularization TABLE 2: The study collection's clinical phenotypes and the number of their specimens.
Wang, J.J., Foran, S., Smith, W., et al.: Risk of Age-Related Macular Degeneration in Eyes with Macular Drusen
or Hyperpigmentation: The Blue Mountains Eye Study Cohort.
Its scanning laser ophthalmoscope technology captures detailed confocal images of the retina so precise that structures commonly missed by fundus cameras, such as macular drusen
and holes, are visualised.
(1) It is characterised by macular drusen
, which can have various compositions but is essentially localised deposits of lipofuscin between the RPE and Bruch's membrane.
In January 2010 her VA in her right eye had improved to 6/7.5 and there was a further improvement to 6/61 when she was reviewed again in March 2011; there was a corresponding reduction in macular drusen
too, as shown in Figure 6.
Abophic (dry) macular degeneration with retinal RPE detachment at the posterior pole and diffuse macular drusen