Reaven, an endocrinologist who directs the Diabetes Research Program at the University of Arizona and VA Health Care System, Phoenix, noted that, while a consistent body of evidence supports an association between higher levels of glucose and increased risk for CVD, it's not as clear that tight control efforts decrease a patient's risk for CVD at the microvascular and macrovascular
Diabetes is associated with increased incidence of macrovascular
disease, particularly cardiovascular disease (CVD), including coronary heart disease, stroke and peripheral vascular disease, which is the major cause of morbidity and mortality in people with diabetes (2,3).
Metformin: effects on micro and macrovascular
complications in type 2 diabetes.
The subjects were compared as regarding the presence of microvascular and macrovascular
Diagnostic cardiac catheters rabbits or macrovascular
angiogrfikhoz: - Pigtail catheters linear 5-6 M 100-110 cm in length.
Examples of macrovascular
complications are narrowing of the heart and brain arteries leading to heart attack and stroke.
The majority of the included studies were randomized, controlled trials, with 98 assessing all-cause mortality and macrovascular
and microvascular outcomes.
In another landmark PROACTIVE trial (Prospective pioglitazone Clinical Trial In macrovascular
Events) , Wilcox R et al ,shared similar results and showed improvement in HDL levels but found an association with heart failure.
complications including end stage renal disease and coronary artery disease.
There would also be a corresponding increase in macrovascular
complications are the leading cause of death and disability causing 70-80% of deaths in diabetic patients .
This review focuses on the developments that have added to the available therapeutic armamentarium, and introduces data to support early rigorous but safe intervention so that the progressive adverse microvascular and in particular macrovascular
complications may be reduced.