Macrothrombocyte | definition of macrothrombocyte by Medical dictionary
A platelet that is larger than usual—e.g., the size of an RBC—a finding typical of Bernard-Soulier syndrome (BSS); up to 10% of normal platelets are ‘giant’—i.e., ‘squashed’ and oversized
DiffDx When > 20% of platelets are giant: idiopathic thromocytopaenic purpura (ITP), lymphoproliferative disorders, myeloproliferative disorders, reticulocytosis, disseminated intravascular coagulation (DIC), systemic lupus (SLE), grey platelet syndrome, May-Hegglin anomaly, type 2B von Willebrand’s disease, thrombotic thrombocytopaenic purpura (TTP)
macrothrombocyte (măk″rō-thrŏm′bō-sīt) [″ + thrombos, clot, + kytos, cell]
A large platelet seen in some leukemias and rare disorders of platelets.
References in periodicals archive
The slides were entirely scanned for platelet aggregates and/or macrothrombocytes and, if any, the samples were excluded from the study.
If neither aggregates nor macrothrombocytes were found, the red cell: platelet ratio was calculated in the monolayer zone of the smear as follows: