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Related to macrophages: Natural killer cells, Dendritic cells


White blood cells whose job is to destroy invading microorganisms. Listeria monocytogenes avoids being killed and can multiply within the macrophage.
Mentioned in: Listeriosis

macrophages (ma·krō·fāˑ·jz), white blood cells (activated monocytes) that protect the body against infection and foreign substances by breaking them down into antigenic peptides recognized by circulating T cells.
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In addition, xanthoangelol (10, 25 or 50 [micro]M) and 4-hydroxyderricin (5, 10, 25 or 50 [micro]M) inhibited the production of IL-10 and monocyte chemoattractant protein (MCP)-l in M2-polarized macrophages.
Then promastigotes were washed with RPMI-1640 medium and incubated with murine macrophages for 4 h.
The investigators found that the helpful macrophages originate in the embryonic heart and harmful macrophages originate in the bone marrow and could be distinguished by whether they express a protein on their surface called CCR2.
These mutations reduce the ability of alveolar macrophages to remove used surfactant from the lungs of these children.
Morphometric analysis revealed both macrophages and vascularity were highly variable among the four groups (Figure).
The macrophage blood cells were "armed" with a virus which began to replicate after reaching the cancer target.
Evidence of tumour cell cytostasis and cytotoxicity was found in macrophage-tumour cell co-cultures in which cytokine and/or lipopolysaccharides (LPS)-stimulated macrophages inhibited metabolic functioning of co-cultured tumour cells (9).
One of the cytokines involved in the microbicide activity by the macrophages is the tumor necrosis factor alpha (TNF-[alpha]) (Silva et al.
They slip unnoticed into and multiply inside of macrophages, the very immune system cells that the body relies on to seek and destroy invading microbes.
The evaluation of the proportion of polymorphonuclear leukocytes, macrophages, T lymphocytes, and B lymphocytes, as well the relative proportion of neovascularization in skin tissue specimens, was determined by quantitative image analysis (22).
The mechanism proposed is through the ability of the immunoglobulins to induce the expression of the inhibitor Fc[gamma]RIIB receptor on effectors cells, counteracting the activation responses triggered by Fc[gamma]RIIB engagement in macrophages and other immune competent cells.
His evaluation revealed thickened bronchovascular bundles with nodules on thoracic computed tomography, dark black plaques in large airways on bronchoscopy, and carbon-laden macrophages and fibrotic scars on lung biopsy.