macrophage migration inhibitory factor


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macrophage migration inhibitory factor

A 25-kD proinflammatory lymphokine, produced by T cells in response to antigenic stimulus, which inhibits macrophage migration.

Gene
MMIF is encoded by MIF on chromosome 22q11.23.

Activities
Cell-mediated immunity, inflammation and regulation of macrophage function in host defence by suppressing the anti-inflammatory effects of glucocorticoids.
 
Mechanism
Increases intracellular cAMP, polymerises microtubules, stops macrophage progression.
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References in periodicals archive ?
Sun et al., "Current developments of macrophage migration inhibitory factor (MIF) inhibitors," Drug Discovery Today, vol.
Baumert et al., "Effect of macrophage migration inhibitory factor (MIF) gene variants and MIF serum concentrations on the risk of type 2 diabetes: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002," Diabetologia, vol.
* The report provides a snapshot of the global therapeutic landscape for Macrophage Migration Inhibitory Factor (Glycosylation-Inhibiting Factor or L-Dopachrome Isomerase or MIF or EC 5.3.2.1)
Nishihira, "Macrophage migration inhibitory factor levels in the vitreous of patients with proliferative diabetic retinopathy," British Journal of Ophthalmology, vol.
Macrophage migration inhibitory factor: a regulator of innate immunity.
Metz, "Macrophage migration inhibitory factor deficiency is associated with altered cell growth and reduced susceptibility to Ras-mediated transformation," The Journal of Biological Chemistry, vol.
Macrophage migration inhibitory factor (MIF), one versatile protein, influences several, even almost all of other transducing signals here or there, which consequently overbalances the systemic circulation and hemodynamic homeostasis.
The proinflammatory mediator macrophage migration inhibitory factor induces glucose catabolism in muscle.
Macrophage migration inhibitory factor is associated with positive cultures in patients with sepsis after cardiac surgery.
NEW YORK -- Macrophage migration inhibitory factor, a newly characterized cytokine that inhibits cortisol and increases production of inflammatory cytokines, may be the key to understanding depression during pregnancy, Brad D.
One of the proteins in the cascade of reactions responsible for killing pancreatic cells is called macrophage migration inhibitory factor (MIF).
AVANIR Pharmaceuticals (San Diego, CA; 310-996-7458) announced that it has acquired a macrophage migration inhibitory factor (MIF) technology from the Ciblex Corporation (San Diego, CA; 619-546-7848).

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