matrix metalloproteinase 12

(redirected from macrophage metalloelastase)

matrix metalloproteinase 12

An enzyme encoded on chromosome 11q22.3 which degrades extracellular matrix and other tissue substrates.

Cytokine inducers
CD40L, GM-CSF, IL-1β, IL-13, MCP-1, M-CSF, PDGF-BB, TNF-α, VEGF.
 
Substrates
Collagen IV; gelatin; elastin and k-elastin; casein; α1-AT; fibronectin; vitronectin; laminin; entactin; proteoglycan monomer; GST-TNF; MBP; fibrinogen; fibrin; plasminogen.
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References in periodicals archive ?
Shay et al., "Acute cigarette smokeinduced connective tissue breakdown requires both neutrophils and macrophage metalloelastase in mice," American Journal of Respiratory Cell and Molecular Biology, vol.
Ultraviolet modulation of human macrophage metalloelastase in human skin in vivo.
Immunohistochemical data showed that monocytes/macrophages drilled these tunnels using the proteolytic enzyme mouse macrophage metalloelastase. DNA synthesis and the neoendothelial markers present in the microvasculature of MCP-1 mouse hearts indicated an active angiogenic process.

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