matrix metalloproteinase 12

(redirected from macrophage metalloelastase)

matrix metalloproteinase 12

An enzyme encoded on chromosome 11q22.3 which degrades extracellular matrix and other tissue substrates.

Cytokine inducers
CD40L, GM-CSF, IL-1β, IL-13, MCP-1, M-CSF, PDGF-BB, TNF-α, VEGF.
 
Substrates
Collagen IV; gelatin; elastin and k-elastin; casein; α1-AT; fibronectin; vitronectin; laminin; entactin; proteoglycan monomer; GST-TNF; MBP; fibrinogen; fibrin; plasminogen.
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References in periodicals archive ?
Ultraviolet modulation of human macrophage metalloelastase in human skin in vivo.
Immunohistochemical data showed that monocytes/macrophages drilled these tunnels using the proteolytic enzyme mouse macrophage metalloelastase.

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