Macrophage inflammatory proteins: Biology and role in pulmonary inflammation.
* The report provides a snapshot of the global therapeutic landscape for C-C Chemokine Receptor Type 1 (HM145 or LD78 Receptor or Macrophage Inflammatory Protein 1-Alpha Receptor or CD191 or CCR1)
* The report reviews C-C Chemokine Receptor Type 1 (HM145 or LD78 Receptor or Macrophage Inflammatory Protein 1-Alpha Receptor or CD191 or CCR1) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
Therapeutic methods referred to modulate the activation of PMNs, such as specific inhibitor of neutrophil elastase (NE)-N-[2-[4-(2,2-dimethyl-1-oxopropoxy) phenyl] sulfonyl] amino] benzoyl]-(S)-glycine monosodium salt (Sivelestat) administration, [sup][6]
macrophage inflammatory protein 2 (MIP-2) (one of PMN chemotactic factors) receptor knockout [sup][7] are seemed to attenuate the severity of VILI.
Abe, T Oshima et al., "Ability of myeloma cells to secrete
macrophage inflammatory protein (MIP)-1[alpha] and MIP-1[beta] correlates with lytic bone lesions in patients with multiple myeloma," British Journal of Haematology, vol.
Boddeke, "Localization of
macrophage inflammatory protein: macrophage inflammatory protein-1 expression in rat brain after peripheral administration of lipopolysaccharide and focal cerebral ischemia," Neuroscience, vol.
These mediators included TNF-[alpha], fibroblast growth factor (FGF) 9, interferon (IFN) [gamma], IFN-[gamma]-inducible protein (IP) 10, RANTES, IL-17A, IL-12p70, IL-11, IL-10, IL-7, IL-6, IL-1[alpha], lymphotactin, oncostatin-M (OSM), growth-regulated [alpha] protein (KC/GRO), stem cell factor (SCF),
macrophage inflammatory protein (MIP)-1[beta], MIP-2, tissue inhibitor of metalloproteinase (TIMP)-1, vascular endothelial growth factor (VEGF)-A, monocyte chemotactic protein (MCP)-1, MCP-3, and MCP-5.
Macrophage inflammatory proteins 1 and 2: expression by rat alveolar macrophages, fibroblasts, and epithelial cells and in rat lung mineral dust exposure.