Macrophage inflammatory protein | definition of macrophage inflammatory protein by Medical dictionary
macrophage inflammatory protein
Also found in: Acronyms
mac·ro·phage in·flam·ma·to·ry pro·tein (MIP),
a member of the chemokine family that is chemotactic for certain lymphocyte subsets such as T-cytotoxic cells.
macrophage inflammatory protein Either of two chemokines—CCL3 (formerly MIP 1α) and CCL4 (formerly MIP 1β)—that are ligands for the CCR5 receptor. Both are produced by macrophages in response to bacterial endotoxins; activate granulocytes (neutrophils, eosinophils and basophils), leading to acute (neutrophilic) inflammation; and induce the synthesis and release of other pro-inflammatory cytokines (e.g., IL-1, IL-6 and TNFalpha) from fibroblasts and macrophages. CCL3 and CCL4 block the entry of M-tropic strains of HIV into various white cells.
References in periodicals archive
The report provides a snapshot of the global therapeutic landscape for C-C Chemokine Receptor Type 1 (HM145 or LD78 Receptor or Macrophage Inflammatory Protein
1-Alpha Receptor or CD191 or CCR1)
2005), and the PMN chemoattractant macrophage inflammatory protein
2 (MIP-2) (Driscoll et al.
The induction of macrophage inflammatory protein
(MIP)-alpha by Z-100, a M.
Macrophage Inflammatory Protein
Gamma 17-Sep-1996 5,556,767 2.