macrophage inflammatory protein


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mac·ro·phage in·flam·ma·to·ry pro·tein (MIP),

a member of the chemokine family that is chemotactic for certain lymphocyte subsets such as T-cytotoxic cells.

macrophage inflammatory protein

Either of two chemokines—CCL3 (formerly MIP 1α) and CCL4 (formerly MIP 1β)—that are ligands for the CCR5 receptor. Both are produced by macrophages in response to bacterial endotoxins; activate granulocytes (neutrophils, eosinophils and basophils), leading to acute (neutrophilic) inflammation; and induce the synthesis and release of other pro-inflammatory cytokines (e.g., IL-1, IL-6 and TNFalpha) from fibroblasts and macrophages. CCL3 and CCL4 block the entry of M-tropic strains of HIV into various white cells.
References in periodicals archive ?
Macrophage inflammatory proteins: Biology and role in pulmonary inflammation.
* The report provides a snapshot of the global therapeutic landscape for C-C Chemokine Receptor Type 1 (HM145 or LD78 Receptor or Macrophage Inflammatory Protein 1-Alpha Receptor or CD191 or CCR1)
* The report reviews C-C Chemokine Receptor Type 1 (HM145 or LD78 Receptor or Macrophage Inflammatory Protein 1-Alpha Receptor or CD191 or CCR1) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
Therapeutic methods referred to modulate the activation of PMNs, such as specific inhibitor of neutrophil elastase (NE)-N-[2-[4-(2,2-dimethyl-1-oxopropoxy) phenyl] sulfonyl] amino] benzoyl]-(S)-glycine monosodium salt (Sivelestat) administration, [sup][6] macrophage inflammatory protein 2 (MIP-2) (one of PMN chemotactic factors) receptor knockout [sup][7] are seemed to attenuate the severity of VILI.
Abe, T Oshima et al., "Ability of myeloma cells to secrete macrophage inflammatory protein (MIP)-1[alpha] and MIP-1[beta] correlates with lytic bone lesions in patients with multiple myeloma," British Journal of Haematology, vol.
Boddeke, "Localization of macrophage inflammatory protein: macrophage inflammatory protein-1 expression in rat brain after peripheral administration of lipopolysaccharide and focal cerebral ischemia," Neuroscience, vol.
These mediators included TNF-[alpha], fibroblast growth factor (FGF) 9, interferon (IFN) [gamma], IFN-[gamma]-inducible protein (IP) 10, RANTES, IL-17A, IL-12p70, IL-11, IL-10, IL-7, IL-6, IL-1[alpha], lymphotactin, oncostatin-M (OSM), growth-regulated [alpha] protein (KC/GRO), stem cell factor (SCF), macrophage inflammatory protein (MIP)-1[beta], MIP-2, tissue inhibitor of metalloproteinase (TIMP)-1, vascular endothelial growth factor (VEGF)-A, monocyte chemotactic protein (MCP)-1, MCP-3, and MCP-5.
Macrophage inflammatory proteins 1 and 2: expression by rat alveolar macrophages, fibroblasts, and epithelial cells and in rat lung mineral dust exposure.

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