'In one trial, we gave haptoglobin to our model anemic mice before transfusing them and blocked macrophage activation
, so they did not develop NEC-like symptoms,' Maheshwari says.
Curcumin alleviates macrophage activation
and lung inflammation induced by influenza virus infection through inhibiting the NF-KB signaling pathway.
Hypercytokinemia accompanied by severe clinical disease seen in EVD is reminiscent of what has been described for macrophage activation
syndrome (MAS) and hemophagocytic lymphohistiocytosis (HLH).
Transcriptome-based network analysis reveals a spectrum model of human macrophage activation
. Immunity 2014;40:274-88.
Lazar's team found that the TZDs, working through PPAR gamma, promote the metabolism of an amino acid called glutamine, a protein building block necessary for macrophage activation
syndrome following initiation of etanercept in a child with systemic onset juvenile rheumatoid arthritis.
It carries severe morbidity of the joints and mortality when persistent systemic features leading to macrophage activation
syndrome in some cases.
syndrome (MAS) is a potentially fatal complication of systemic juvenile idiopathic arthritis (sJIA), caused by an exaggerated but ineffective immune response involving excessive macrophage and T cell activation, followed by high production of proinflammatory cytokines (1-3).
The abundance of epithelioid macrophages and lymphocytes in the granulomas at 28 dpi, may indicate that at this stage the triggered immune response is TH1-type, as in this type of response occurs a strong activation of T lymphocytes, inducers of an intense macrophage activation
His immunological studies focused on the mechanism of macrophage activation
and human immunodeficiency virus infection: HIV replication directs macrophages towards a proinflammatory phenotype while previous activation modulates macrophage susceptibility to infection and viral production.
Nearly 10% of children with systemic lupus erythematosus (SLE) developed macrophage activation
syndrome (MAS) at some point during a mean follow-up time of more than 3 years at one center, and most were concomitantly diagnosed with the syndrome.