macrolide antibiotic


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macrolide antibiotic

Infectious disease A broad-spectrum antibiotic–eg, erythromycin, produced by Streptomyces spp, that contains a lactone ring and inhibits protein synthesis in target bacteria. See Antibiotic resistance.
References in periodicals archive ?
Possible cardiac adverse effects of therapeutic doses of macrolide antibiotics (azithromycin and clarithromycin) in healthy juvenile rats: biochemical assessment.
Clarithromycin is a potent macrolide antibiotic employed for the treatment of different bacterial diseases.
Influence of a macrolide antibiotic, roxithromycin, on mast cell growth and activation in vitro.
Coadministering a cytochrome P450 isoenzyme 3A4 (CYP3A4)inhibiting macrolide antibiotic, such as clarithromycin or erythromycin) (but not azithromycin) with atorvastatin (Lipitor[R]), simvastatin (Zocor[R]), or lovastatin (Mevacor[R]), which are metabolized by CYP3 A4, is associated with a fourfold to 10-fold increase in statin concentrations.
It is the first macrolide antibiotic available in a stable eye drop formulation, with a broad spectrum adapted to the vast majority of bacteria responsible for common eye infections.
Use of the macrolide antibiotic was associated with a significantly greater incidence of hearing decrement, although the overall rate was low and tended to reverse when the drug was stopped, Dr.
Of those patients, 176 had been prescribed a macrolide antibiotic (examples are azithromycin, clarithromycin and erythromycin).
The researchers then identified those who were hospitalized for low blood pressure and, in that group, whether or not a macrolide antibiotic had been prescribed shortly beforehand.
Patients were interviewed and their medical records were abstracted to collect race/ethnicity, clinical laboratory tests, renal imaging studies, renal biopsy results, history of diabetes mellitus, hypertension, hepatitis B and C, syphilis, injection drug use, dialysis, and macrolide antibiotic and tetracycline use prior to the diagnosis of renal disease.
The use of a macrolide antibiotic in infancy was related to a 1.8-fold increased risk of AD, while cephalosporins were associated with a 1.7-fold risk.
The Sandoz generics unit of Novartis AG has also launched its version of the macrolide antibiotic in suspension form.