Possible cardiac adverse effects of therapeutic doses of macrolide antibiotics
(azithromycin and clarithromycin) in healthy juvenile rats: biochemical assessment.
Clarithromycin is a potent macrolide antibiotic
employed for the treatment of different bacterial diseases.
Influence of a macrolide antibiotic
, roxithromycin, on mast cell growth and activation in vitro.
The structure of the aglycone of the macrolide antibiotic
Coadministering a cytochrome P450 isoenzyme 3A4 (CYP3A4)inhibiting macrolide antibiotic
, such as clarithromycin or erythromycin) (but not azithromycin) with atorvastatin (Lipitor[R]), simvastatin (Zocor[R]), or lovastatin (Mevacor[R]), which are metabolized by CYP3 A4, is associated with a fourfold to 10-fold increase in statin concentrations.
It is the first macrolide antibiotic
available in a stable eye drop formulation, with a broad spectrum adapted to the vast majority of bacteria responsible for common eye infections.
Use of the macrolide antibiotic
was associated with a significantly greater incidence of hearing decrement, although the overall rate was low and tended to reverse when the drug was stopped, Dr.
Of those patients, 176 had been prescribed a macrolide antibiotic
(examples are azithromycin, clarithromycin and erythromycin).
The researchers then identified those who were hospitalized for low blood pressure and, in that group, whether or not a macrolide antibiotic
had been prescribed shortly beforehand.
Patients were interviewed and their medical records were abstracted to collect race/ethnicity, clinical laboratory tests, renal imaging studies, renal biopsy results, history of diabetes mellitus, hypertension, hepatitis B and C, syphilis, injection drug use, dialysis, and macrolide antibiotic
and tetracycline use prior to the diagnosis of renal disease.
The use of a macrolide antibiotic
in infancy was related to a 1.8-fold increased risk of AD, while cephalosporins were associated with a 1.7-fold risk.
The Sandoz generics unit of Novartis AG has also launched its version of the macrolide antibiotic
in suspension form.