macrolide


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macrolide

 [mak´ro-līd]
1. a chemical compound characterized by a large lactone ring containing multiple keto and hydroxyl groups.
2. any of a group of antibacterial antibiotics containing such a ring linked to one or more sugars.

mac·ro·lide

(mak'rō-līd),
A natural lactone with a large ring; usually consisting of 14-20 atoms; macrolides include a class of antibiotics discovered in streptomycetes, for example, erythromycin; macrolides also inhibit protein biosynthesis.

macrolide

/mac·ro·lide/ (mak´ro-līd)
1. a compound characterized by a large lactone ring with multiple keto and hydroxyl groups.
2. any of a group of antibiotics containing this ring linked to one or more sugars, produced by certain species of Streptomyces.

macrolide

(măk′rō-līd)
n.
A class of antibiotics that are produced by certain actinomycetes of the genus Streptomyces, are characterized by a large lactone ring linked to one or more sugars, and act by inhibiting protein synthesis.

macrolide

A natural lactone with a large (14–20) carbon ring structure that inhibits protein synthesis; e.g., erythromycin.

mac·ro·lide

(mak'rō-līd)
A natural lactone, with a large ring, usually of 14-20 atoms; several antibiotics, including erythromycin, are macrolides. They inhibit protein biosynthesis.

macrolide

One of a range of antibiotics with a wide spectrum of action that can be used as an alternative to the penicillins to treat respiratory infections including LEGIONNAIRES' DISEASE. The group includes erythromycin, azithromycin and clarithromycin.

macrolide

as in antibiotic; any antibiotic with molecules having many-membered lactone rings, e.g. erythromycin, spiramycin, tylosin.
References in periodicals archive ?
A couple of decades ago, you could comfortably treat a patient with severe community-acquired pneumonia with a macrolide, but you can't do that anymore," he said.
We found a 23S rRNA point mutation A2063G known to confer macrolide resistance in 10 (10.
Phase I: API for Azithromycin and other macrolide intermediaries with 240 ton annual capacity.
Macrolide resistance in group A beta haemolytic Streptococcus isolated from outpatient children in Latvia.
Biotica Technology Limited, a privately-held biotechnology company, announces a significant Collaboration and License Agreement with GlaxoSmithKline to discover, develop and commercialise novel erythromycin-based macrolides in inflammatory diseases.
Typically, all of these mechanisms for macrolide resistance are represented in a given patient population.
These apparently selective inhibitory effects of macrolides on the production of pneumolysin by both macrolide-susceptible and macrolide-resistant strains of the pneumococcus may provide an explanation for the benefit of combining these agents with beta-lactams on the outcome of bacteraemic pneumococcal pneumonia.
Continued monitoring of resistance rates will be needed to alert practitioners of possible treatment failures due to macrolide resistance.
Of note, the frequency of sulfa and macrolide allergies observed in both the PTA and PTC groups in our study are consistent with accepted values reported in the literature.
Although we anticipate that solithromycin will become available only in the United States and its prescriptions will be reserved primarily for patients failing marketed macrolides, the wide use of macrolides in inpatients and outpatients and solithromycin's availability in both oral and IV formulations will enable the drug to garner combined sales of nearly $100 million in 2021," said Decision Resources Therapeutic Area Director Irene Koulinska, M.
Clinical cure rate at day 14 was 32 out of 36 patients given any macrolide, and 11 out of 12 given macrolide monotherapy.
In Europe, reports of macrolide resistance have ranged from 3% in Germany to 9.