macrolide

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macrolide

[mak´ro-līd]

1. a chemical compound characterized by a large lactone ring containing multiple keto and hydroxyl groups.

2. any of a group of antibacterial antibiotics containing such a ring linked to one or more sugars.

mac·ro·lide

(mak'rō-līd),

A natural lactone with a large ring; usually consisting of 14-20 atoms; macrolides include a class of antibiotics discovered in streptomycetes, for example, erythromycin; macrolides also inhibit protein biosynthesis.

macrolide

(măk′rō-līd)

A class of antibiotics that are produced by certain actinomycetes of the genus Streptomyces, are characterized by a large lactone ring linked to one or more sugars, and act by inhibiting protein synthesis.

macrolide

A natural lactone with a large (14–20) carbon ring structure that inhibits protein synthesis; e.g., erythromycin.

mac·ro·lide

(mak'rō-līd)

A natural lactone, with a large ring, usually of 14-20 atoms; several antibiotics, including erythromycin, are macrolides. They inhibit protein biosynthesis.

macrolide

One of a range of antibiotics with a wide spectrum of action that can be used as an alternative to the penicillins to treat respiratory infections including LEGIONNAIRES' DISEASE. The group includes erythromycin, azithromycin and clarithromycin.

References in periodicals archive ?

Drug induced cardiotoxicity remains a major limitation in standard and high dose macrolide antibiotics.

Toxicity evaluation of tilmicosin under in Vitro and in vivo conditions

Increased macrolide resistance of Mycoplasma pneumoniae in pediatric patients with community-acquired pneumonia.

Multilocus Sequence Typing of Mycoplasma pneumoniae, Japan, 2002-2016

High prevalence of macrolide resistance in Mycoplasma pneumoniae isolates from adult and adolescent patients with respiratory tract infection in China.

A study of community-acquired Mycoplasma pneumoniae in Yantai, China/Estudio de Mycoplasma pneumoniae adquirido en la comunidad en Yantai, China

Macrolide is leveraging its proprietary chemistry platform to re-engineer the macrolide scaffold with the aim of developing a new fully-synthetic macrolide antibiotic to treat drug-resistant Gram-negative infections that can be administered intravenously and orally.

CARB-X Awards Macrolide Pharmaceuticals USD 6.8m to Develop Macrolide Antibiotics with Gram-Negative Activity

Approximately 3 years ago, the FDA strengthened warnings regarding the risk of QT interval prolongation and torsades de pointes with the macrolide azithromycin.

Community-acquired bacterial pneumonia: is there anything new?

Bodhidatta et al., "Emerging fluoroquinolone and macrolide resistance of Campylobacter jejuni and Campylobacter coli isolates and their serotypes in Thai children from 1991 to 2000," Epidemiology and Infection, vol.

Virulence and Antimicrobial Resistance in Campylobacter spp. from a Peruvian Pediatric Cohort

High local concentrations of macrolide antibiotics can overcome this type of resistance mechanism, resulting in good clinical efficacy despite in vitro resistance.

Treatment of Community-Acquired Pneumonia: A Case Report and Current Treatment Dilemmas

[16] 57 Undetermined Yes Reference Antimicrobial class (quinolone, Outcome macrolide, or both quinolone and macrolide) Koufakis et al.

Legionnaires' Disease Complicated with Rhabdomyolysis and Acute Kidney Injury in an AIDS Patient

Although many strains of the primary CABP pathogen, Streptococcus pneumoniae, are resistant to currently-approved macrolides, this class of antibiotic remains among the most commonly prescribed antibacterial drugs for CABP in both the hospital and community settings.

Cempra files Solithera NDA with US FDA for community-acquired bacterial pneumonia treatment

This has renewed interest regarding the use of macrolide, lincosamides, and type B streptogramin antimicrobials for the treatment of staphylococcal infections.

Phenotypic and molecular characterization of resistance to macrolides, lincosamides and type B streptogramin of clinical isolates of Staphylococcus spp. of a university hospital in Recife, Pernambuco, Brazil

The macrolide resistance phenotype was detected by means of the double disc diffusion test, using the erythromycin and clindamycin discs placed 15 mm apart from each other.

Susceptibility of respiratory isolates of Streptococcus pneumoniae isolated from children hospitalized in the Clinical Center Nis/Osetljivost respiratornih izolata Streptococcus pneumoniae dobijenih iz materijala dece hospitalizovane u klinickom centru nis

MONTREAL -- A new, next-generation macrolide, solithromycin, showed safety and efficacy as a once-daily oral agent that was noninferior to the comparator oral antibiotic, the fluoroquinolone moxifloxacin, in a phase III trial.