macroglobulinemia


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Related to macroglobulinemia: Waldenstrom's macroglobulinemia

macroglobulinemia

 [mak″ro-glob″u-lin-e´me-ah]
increased levels of macroglobulins in the blood.
Waldenström's macroglobulinemia a type of plasma cell dyscrasia with cells having lymphocytic, plasmacytic, or intermediate morphology and secreting IgM M-component. There is diffuse infiltration of bone marrow and in many cases also of the spleen, liver, or lymph nodes. The circulating macroglobulin produces symptoms of hyperviscosity syndrome: weakness, fatigue, bleeding disorders, and visual disturbances. Peak incidence is in the sixth and seventh decades.

mac·ro·glob·u·lin·e·mi·a

(mak'rō-glob'yū-li-nē'mē-ă),
The presence of increased levels of macroglobulins in the circulating blood.

macroglobulinemia

(măk′rō-glŏb′yə-lə-nē′mē-ə)
n.
A condition marked by an abnormally high concentration of macroglobulins in the blood serum.

mac·ro·glob·u·lin·e·mi·a

(mak'rō-glob'yū-li-nē'mē-ă)
Increased levels of macroglobulins in the blood.
Synonym(s): macroglobulinaemia.
References in periodicals archive ?
Immunophenotypic profile of lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia.Am J Clin Pathol.
Waldenstrom's macroglobulinemia: incidence patterns in the united states, 1988-1994.
We report a patient with lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia with monoclonal IgM k paraproteinemia who, 9 years after initial diagnosis, developed Burkitt lymphoma with acquisition of a MYC translocation.
Calquence is being developed for the treatment of multiple B-cell blood cancers including CLL, MCL, diffuse large B-cell lymphoma, Waldenstrom macroglobulinemia, follicular lymphoma, and multiple myeloma and other hematologic malignancies.
This will likely prove definitive in the head-to-head Phase III trials to read out later in the year in Waldenstrom macroglobulinemia, Van Buren tells investors in a research note titled "The BeiGene Global Portfolio Development Strategy Remains On Track." Further, the analyst finds the combo's activity in chronic lymphocytic leukemia/small lymphocytic lymphoma and Hodgkin's lymphoma "promising."
Summary: Waldenstrom macroglobulinemia is a rare cancer and is characterized by high level of immunoglobulin M (IgM) in the serum, which leads to increased serum viscosity, and presence of a lymphoplasmacytic infiltrate in the bone marrow.
[UKPRwire, Wed Apr 24 2019] The global NavigaWaldenstrom Macroglobulinemia Market is segmented into North America, Latin America, Europe, Asia-Pacific excluding Japan (APEJ), Japan and the Middle East and Africa (MEA).
Two Type II Variation Applications were submitted to EMA for the expanded use of IMBRUVICA (ibrutinib) in combination with obinutuzumab in previously untreated adults with chronic lymphocytic leukemia and in combination with rituximab for the treatment of previously untreated and relapsed/refractory adults with Waldenstrom's macroglobulinemia.
(29) The MYD88 mutations are frequent and occur in more than 95% of patients with lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia, but are uncommon in MZL and other low-grade B-cell lymphomas.
These included 7 with relapsed/refractory CLL, two with mantle cell lymphoma (MCL), and two with Waldenstrom macroglobulinemia (WM).
The second is for use of ibrutinib and rituximab for the treatment of earlier untreated and relapsed/refractory adults with Waldenstrom's macroglobulinemia. Ibrutinib is a first-in-class Bruton's tyrosine kinase inhibitor that is jointly developed and commercialised by Janssen Biotech Inc, and Pharmacyclics LLC, an AbbVie company.