macroglobulin


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macroglobulin

 [mak″ro-glob´u-lin]
a protein (globulin) of high molecular weight, in the range of 1,000,000; observed in the blood in a number of diseases.
α2-macroglobulin a plasma protein that inhibits a wide variety of proteolytic enzymes, including trypsin, plasmin, thrombin, kallikrein, and chymotrypsin, by entrapping and reducing the accessibility of their functional sites to large molecules. Written also alpha2-macroglobulin.

macroglobulin

/mac·ro·glob·u·lin/ (mak″ro-glob´ūl-in) a globulin of unusually high molecular weight, in the range of 1,000,000.
α2-macroglobulin  a plasma protein that inhibits a wide variety of proteolytic enzymes, including trypsin, plasmin, thrombin, kallikrein, and chymotrypsin, by entrapping and reducing the accessibility of their functional sites to large molecules.

macroglobulin

(măk′rō-glŏb′yə-lĭn)
n.
A plasma globulin of high molecular weight.

macroglobulin

[-glob′yəlin]
a globular serum protein with a molecular mass above 400 kilodaltons, such as the proteinase inhibitor alpha2-macroglobulin. See also immunoglobulin M.

macroglobulin

Any large serum protein, usually ≥ 400 kD—e.g., IgM (900 kD), α2-macroglobulin (820 kD). Macroglobulins are detected by sharp peaks on a simple zone electrophoresis, usually in the gamma region; because of the differing charges on the radicals, the electrophoretic mobility (pI) on the agar may shift and monoclonal spikes may occur in the beta or, less commonly, in the alpha region.

macroglobulin

Any large serum protein, usually ≥ 400 kD–eg, IgM–900 kD, α2-macroglobulin–820 kD; macroglobulins are detected by sharp peaks on a simple zone electrophoresis, usually in the γ-region

macroglobulin

See IgM.

macroglobulin

immunoglobulin M, an antibody protein (globulin) of molecular weight in the range of 1,000,000.

α2-macroglobulin
a glycoprotein that inhibits proteolytic enzymes. Increased levels are seen in diabetes mellitus and diseases of the liver and kidney.
References in periodicals archive ?
Alpha-2 macroglobulin attaches to the same cell surface protein as APP and APOE, the products of two other genes involved in Alzheimer's disease.
It's unclear how the identified mutation, a small deletion, affects alpha2 macroglobulin.
f ) Hepascore: A model of four serum markers bilirubin glutamyl transferase HA macroglobulin along with age and gender forms hepascore.
Three most recognizable of them are [alpha]1 anti chymotrypsin (ACT), [alpha]1 macroglobulin & [alpha]1 protein inhibitor.
2] macroglobulin (A2M), haptoglobin (HPT), complement 3c (C3c), complement 4 (C4), IgA, IgG, and IgM and to the First International Standard CRP 85/ 506 for C-reactive protein (CRP).
Currently the most reliable serologic assessment of liver fibrosis uses a panel of 5 markers: [alpha]2 macroglobulin (a2M), haptoglobin, apolipoprotein [alpha]1 , y-glutamyl transpeptidase, and bilirubin (4).
FT is a noninvasive blood test that combines the quantitative results of 5 serum biochemical markers (alpha2 macroglobulin, haptoglobin, gamma glutamyl transpeptidase, total bilirubin, and apolipoprotein A1) with the patient's age and gender in a patented artificial intelligence algorithm (U.