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a protein (globulin) of high molecular weight, in the range of 1,000,000; observed in the blood in a number of diseases.
α2-macroglobulin a plasma protein that inhibits a wide variety of proteolytic enzymes, including trypsin, plasmin, thrombin, kallikrein, and chymotrypsin, by entrapping and reducing the accessibility of their functional sites to large molecules. Written also alpha2-macroglobulin.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
A plasma globulin of high molecular weight.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
macroglobulinAny large serum protein, usually ≥ 400 kD—e.g., IgM (900 kD), α2-macroglobulin (820 kD). Macroglobulins are detected by sharp peaks on a simple zone electrophoresis, usually in the gamma region; because of the differing charges on the radicals, the electrophoretic mobility (pI) on the agar may shift and monoclonal spikes may occur in the beta or, less commonly, in the alpha region.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
macroglobulinAny large serum protein, usually ≥ 400 kD–eg, IgM–900 kD, α2-macroglobulin–820 kD; macroglobulins are detected by sharp peaks on a simple zone electrophoresis, usually in the γ-region
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005