macrocytic


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macrocytic

/mac·ro·cyt·ic/ (-sit´ik) pertaining to or characterized by macrocytes.

macrocytic

[mak′rōsit′ik]
Etymology: Gk, makros + kytos + L, icus, form
(of a cell) larger than normal, such as the erythrocytes in macrocytic anemia.

macrocytic

adjective Referring to enlarged cells or red blood cells.

anemia

Hematology A condition characterized by ↓ RBCs or Hb in the blood, resulting in ↓ O2 in peripheral tissues Clinical Fatigability, pallor, palpitations, SOB; anemias are divided into various groups based on cause–eg, iron deficiency anemia, megaloblastic anemia–due to ↓ vitamin B12 or folic acid, or aplastic anemia–where RBC precursors in BM are 'wiped out'. See Anemia of chronic disease, Anemia of investigation, Anemia of prematurity, Aplastic anemia, Arctic anemia, Autoimmune hemolytic anemia, Cloverleaf anemia, Congenital dyserythropoietic anemia, Dilutional anemia, Dimorphic anemia, Drug-induced immune hemolytic anemia, Fanconi anemia, Hemolytic anemia, Idiopathic sideroblastic anemia, Immune anemia, Iron-deficiency anemia, Juvenile pernicious anemia, Macrocytic anemia, Megaloblastic anemia, Microcytic anemia, Myelophthisic anemia, Neutropenic colitis with aplastic anemia, Nonimmune hemolytic anemia, Pseudoanemia, Refractory anemia with excess blasts, Sickle cell anemia, Sideroblastic anemia, Sports anemia.
General groups of anemia
Morphology
Macrocytic
Megaloblastic anemia
  • Vitamin B12deficiency
  • Folic acid deficiency
Microcytic hypochromic
  • Iron-deficiency anemia
  • Hereditary defects
  • Sickle cell anemia
  • Thalassemia
  • Other hemoglobinopathies
Normocytic
  • Acute blood loss
  • Hemolysis
  • BM failure
  • Anemia of chronic disease
  • Renal failure
Etiology
Deficiency
  • Iron
  • Vitamin B12
  • Folic acid
  • Pyridoxine
Central–due to BM failure
  • Anemia of chronic disease
  • Anemia of senescence
  • Malignancy
    • BM replacement by tumor
    • Toxicity due to chemotherapy
    • Primary BM malignancy, eg leukemia
Peripheral
  • Hemorrhage
  • Hemolysis
.

Macrocytic

A descriptive term applied to a larger than normal red blood cell.

macrocytic

manifested by or pertaining to the presence of macrocytes.
References in periodicals archive ?
Serum iron (SI) was observed to be lowest in microcytic hypochromic patients whereas it was highest in macrocytic patients.
Our patient had no finding compatible with macrocytic anemia in complete blood count.
We were facing a progressive paraparesis with the level of sensitivity at D6 and a severe hyporegenerative macrocytic anemia.
In the present study, the superior RBCs findings was normocytic normochromic anemia (48%) followed by macrocytic anemia (30%).
The mean HbA1c level and proposed reference ranges for the five anaemia subgroups (anaemia of chronic disease [ACD], iron deficiency anaemia [IDA], mixed anaemia, macrocytic anaemia and sickle-cell disease) are shown in table 2.
The sample showed a mild increase in macrocytic hemophagocytosis and pancytopenia with a hypocellular marrow with myeloid hyperplasia and erythroid hypoplasia (Figure 1, panel B).
If not, they are at risk of developing common symptoms of folate deficiency including diarrhoea, confusion, forgetfulness, irritability, or other cognitive declines, depression, sore or swollen tongue, peptic or mouth ulcers, headaches, palpitations, behavioural disorders, macrocytic anaemia with weakness or shortness of breath, and nerve damage with weakness and limb numbness, studies have shown.
Since late 2007, the patient had developed mild macrocytic anaemia with a borderline low platelet count.
Pour-ons containing synthetic pyrethroids or injections of macrocytic lactones such as ivermectin can help in killing the maggots, and control of bacterial infections can speed healing.
One also has to bear in mind that the vitamin B12 levels can be low independent of Macrocytic anaemia.
Vitamin B12 deficiency is a common cause of macrocytic anemia (pernicious anemia).