macrocytic


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macrocytic

adjective Referring to enlarged cells or red blood cells.

anemia

Hematology A condition characterized by ↓ RBCs or Hb in the blood, resulting in ↓ O2 in peripheral tissues Clinical Fatigability, pallor, palpitations, SOB; anemias are divided into various groups based on cause–eg, iron deficiency anemia, megaloblastic anemia–due to ↓ vitamin B12 or folic acid, or aplastic anemia–where RBC precursors in BM are 'wiped out'. See Anemia of chronic disease, Anemia of investigation, Anemia of prematurity, Aplastic anemia, Arctic anemia, Autoimmune hemolytic anemia, Cloverleaf anemia, Congenital dyserythropoietic anemia, Dilutional anemia, Dimorphic anemia, Drug-induced immune hemolytic anemia, Fanconi anemia, Hemolytic anemia, Idiopathic sideroblastic anemia, Immune anemia, Iron-deficiency anemia, Juvenile pernicious anemia, Macrocytic anemia, Megaloblastic anemia, Microcytic anemia, Myelophthisic anemia, Neutropenic colitis with aplastic anemia, Nonimmune hemolytic anemia, Pseudoanemia, Refractory anemia with excess blasts, Sickle cell anemia, Sideroblastic anemia, Sports anemia.
General groups of anemia
Morphology
Macrocytic
Megaloblastic anemia
  • Vitamin B12deficiency
  • Folic acid deficiency
Microcytic hypochromic
  • Iron-deficiency anemia
  • Hereditary defects
  • Sickle cell anemia
  • Thalassemia
  • Other hemoglobinopathies
Normocytic
  • Acute blood loss
  • Hemolysis
  • BM failure
  • Anemia of chronic disease
  • Renal failure
Etiology
Deficiency
  • Iron
  • Vitamin B12
  • Folic acid
  • Pyridoxine
Central–due to BM failure
  • Anemia of chronic disease
  • Anemia of senescence
  • Malignancy
    • BM replacement by tumor
    • Toxicity due to chemotherapy
    • Primary BM malignancy, eg leukemia
Peripheral
  • Hemorrhage
  • Hemolysis
.

Macrocytic

A descriptive term applied to a larger than normal red blood cell.
References in periodicals archive ?
Among those with anemia, normocytic normochromic (53%) was the most common type of anemia, followed by microcytic (30%) and macrocytic anemia (27%).
On the contrary, a macrocytic morphology was present in only 3.1% of subjects with vitamin [B.sub.12] deficiency.
Furthermore, in the background of macrocytic anemia and a reticulocyte index of 1.04 at presentation, which worsened to Hb of 6.9 mg/dL and Hct of 20.6% on the third day of presentation, the initial serum Vitamin B12 returned to low level (202 pg/mL, normal 211-946 pg/mL) with normal serum folate (5.9 ng/mL, normal > 3.0 ng/mL) in the presence of anti-intrinsic factor (IF) antibody.
Kavuru, "Coprophagia and pica in individuals with mild to moderate dementia and mixed (iron deficiency and macrocytic) anemia," Journal of the American Geriatrics Society, vol.
Occasionally, severe hypochromia is associated with macrocytic red cells, termed leptocytes.
With respect to macrocytic anemia in the initial blood count at the admission of the patient, there were no data of personal or family history of anemia, and this condition was corrected during ambulatory evolution, suggesting a case of possible infectious condition.
Megaloblastic anemia is an anemia that is characterized by the presence of precursor cells, megaloblast in the bone marrow and macrocytic red cells in the peripheral blood.4 These megaloblasts arise because of impaired DNA synthesis followed by ineffective erythropoiesis.4
Surgestone and Provames, are used in a range of women's health indications, Speciafoldine is used to treat macrocytic anemia, while Tredemine is a World Health Organization recognized essential medicine to treat tapeworm.
Supporting the role of autoantibodies in its pathogenesis, Good's syndrome also has many autoimmune manifestations, such as pure red cell aplasia (34.8%), aplastic anemia (7.9), macrocytic anemia (5.6%), and autoimmune hemolytic anemia (3.4) [10].
Although the patient had no evidence of macrocytic anemia in complete blood count, we measured the level of vitamin [B.sub.12] because the patient had hypotonicity and found it to be low.
N's vitamin [B.sub.12] deficiency could have been affecting his mental status; consequently, we ordered routine laboratory work-up that included a complete blood count with differential and peripheral smear, which showed macrocytic anemia and ovalocytes.
*Review the type of anemia and morphologically classify as normocytic normochromic (NCNC), microcytic hypochromic (MCHC) or macrocytic, or hemolytic.