macrocyclic


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macrocyclic

(mak″rō-sik′lik) [ macro- + cyclic]
Composed of two or more linked, ring-shaped chemical structures.
References in periodicals archive ?
The objective of this study is to synthesize certain macrocyclic compounds that could form selective complexes with toxic heavy metals, especially mercury and lead.
Roridin E and Verrucarin A: Roridin E and verrucarin A are macrocyclic trichothecenes produced by the mold genuses Fusarium, Myrothecium, and Stachybotrys (i.
2008), but their assemblages are threatened by the macrocyclic lactones (ML) used to treat endo- and ectoparasites in cattle (Floate, 2011).
and Canada) have formed a two-year collaboration aimed at improving cellular delivery of macrocyclic peptides, a class of molecules that can potentially access therapeutic strategies that have been refractory to traditional approaches.
in livestock has declined in at least some areas where macrocyclic lactone endectocides such as Ivermectin and Doramectin are in use.
In contrast, the macrocyclic chelates offer a strong binding to Gd3+ by the virtue of being preorganized rigid rings of almost optimal size to cage the Gd atom.
The use of chemical anthelmintics is as old as the 1950s when 1st generation broad spectrum anthelmintics including phenothiazine and piperazine were produced after that with the passage of time more advanced and effective anthelmintics evolved as in 1960s containing 2nd generation anthelmintics like imidazothiazoles, benzimidazoles, pro benzimidazoles and tetra-hydro-pyrimidines were produced while in the 1980s a 3rd generation broad spectrum anthelmintics including macrocyclic lactones (Avermectins) have been produced which are still functional and being used by the veterinarians and livestock producers either in the form of injectable or drenching the animals like sheep, goat and cattle etc.
As a dewormer, the macrocyclic lactone ivermectin (Ivomec) is considered to be the most effective against deer worm larvae that haven't yet crossed the bloodbrain barrier (see "Blood-Brain Barrier"on page 88).
immitis resistance to macrocyclic lactones, such as ivermectin, for heartworm chemoprophylaxis.
Introduction The cation selectivity of macrocyclic ligands such as crown ether and cryptands makes them excellent candidates for analytical applications.
In addition, Circle Pharma has begun collaborating with Pfizer on two projects aimed at developing cell permeable macrocyclic peptide therapeutics.