macrocyclic


Also found in: Dictionary, Encyclopedia, Wikipedia.

macrocyclic

(mak″rō-sik′lik) [ macro- + cyclic]
Composed of two or more linked, ring-shaped chemical structures.
References in periodicals archive ?
The milestone is associated with the dosing of the first patient in a Phase 1 clinical trial evaluating an investigational orally-available macrocyclic peptide for a non-complement cardiovascular target with a large market opportunity from the companies' collaboration.
Nimble's proprietary technology enables the synthesis and screening of millions of peptides, including scaffolded natural and modified macrocyclic peptidomimetics.
"While there is clear evidence that all types of [gadolinium contrast agents], both linear and macrocyclic, may result in trace amounts of gadolinium in the brain, there exists no clinical evidence that this leads to an increase in risk or harm to patients," a press release from GE Healthcare defended the company's MRI contrast agent Omniscan; and continued stating that "Omniscan has a specific cardiac indication in several European Member States; removing it would limit clinical choice."
In 2005, concentrations of macrocyclic lactones and insect growth regulators were below the LOD for over 75% of households; in 2011, the levels of the organosulfite insecticide propargite was below the LOD for over 75% of households (Table 1).
Aneja, Macrocyclic metal complexes derived from 2, 6-diaminopyridine and isatin with their antibacterial and spectroscopic studies, Spectrochim.
We are very impressed by the potential of Cyclenium's CMRT Technology and its QUEST Library of macrocyclic molecules.
Fidaxomicin is the first in a new class of macrocyclic antibiotics and lately been licensed by the European Medicines Agency (EMA).
Cypralis and Gilead Sciences have agreed that Cypralis will have exclusive development and commercialization rights to certain macrocyclic inhibitors of peptide bond isomerases, in all fields except for oncology and virology.
Calixarenes are macrocyclic phenolic oligomers with phenolic hydroxyl groups, which are able to coordinate the metal ions very tightly.
In this context, the catalytic model systems more closely related to the CODHs activity are herein described by detailing in the following paragraphs the most representative examples of transition metal compounds based on phosphine or macrocyclic ligands.
Macrocyclic GBCAs, such as Gadovist[R] or Dotaram, exhibited lower dissociation constants, and the molecular structure of macrocyclic GBCAs is more stable than the linear GBCAs [31].