macrocycle


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macrocycle

A several-month period of mezocycles of vigourous training followed by short periods of lighter training, as by an athlete preparing for a competitive sports event.
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Encycle Therapeutics is a Toronto-based biotech company exploiting a unique platform technology that enables the rapid synthesis of drug-like macrocycles or membrane-permeable nacellins.
In the case of macrocycle formation (over nine-membered rings), one expects the same NMR signals as in the case of branching.
Krieg & Whitten [40] suggested that the increased rates of porphyrin photobleaching in the presence of the photooxidizable substrates (diethylsulphide, histidine, cysteine, methionine, and Trp) could result from an attack on the porphyrin macrocycle by reactive [sup.
Porphyrins are highly-absorbing conjugated macrocycles which serve a variety of essential functions in biologically active molecules such as chlorophyll, heme proteins and cyto-chromes; and which have a range of medicinal, industrial and scientific uses.
Ensemble is leveraging its macrocycle drug discovery expertise to fuel its proprietary drug candidate pipeline while also pursuing collaborations with pharmaceutical partners.
In order to develop selective hosts for anions, we have synthesized a new macrocycle L, from the reaction of isophthalaldehyde and N'-methyl-2, 2'-diaminodiethylamine under high dilution conditions in methanol, followed by diborane reduction.
The intervals are dominated by various marlstones which, according to Nestor & Einasto (1997), formed during a transgressive (deepening) phase of the late Llandovery-middle Wenlock macrocycle of basin development.
Each macrocycle is then broken up into three phases, emphasizing general training exercises, special training exercises, and competition-specific exercises.
Coaches can organize a general schema of training through a macrocycle which encompasses an entire month, year, or career of a team or individual, or a microcycle, consisting of weekly, daily, or hourly scheduling of training.
The Cyclenium macrocycle libraries are unique in that they combine the complexities found in natural products with the drug-like properties needed for successful drug discovery.
The traditional periodization theory advocates that training loads with distinct orientations should be distributed along a macrocycle in order to allow athletes to achieve peak performance in the most important competition of the period (Fleck, 1999; Kraemer et al.
It should be understood that the tetrapyrrole unit is a highly conjugated, nearly planar macrocycle with 22 delocalized bonding [pi]-electrons, obeying the well-known Huckel's 4n+2 rule (where n is an integer number) for stability or aromaticity of ring structure.