macrocrania


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macrocrania

 [mak″ro-kra´ne-ah]
abnormal increase in size of the skull in relation to the face.

macrocrania

/mac·ro·cra·nia/ (-kra´ne-ah) abnormal increase in the size of the skull, the face appearing small in comparison.

macrocrania

Having an abnormally large skull in proportion to the size of the face.

macrocrania

abnormal increase in size of the skull in relation to the face.
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b) In infants and older children: Macrocrania, prominant superficial cranial veins, developmental delay, failure to thrive, hydrocephalus, seizures, headache and hepatic failure.
The clinical features include macrocrania, distinct facial features, and usually developmental delay owing to the CNS involvement.
Proteus syndrome may mimic MDL owing to its asymmetric overgrowth of bones and adipose tissue; however, associated features of macrocrania, intracranial abnormalities, cutaneous thickening, pigmented naevi, lung cysts and intra-abdominal lipomas distinguish it from MDL.
The most common abnormality of the skull includes macrocrania, hypoplasia of the greater wing of the sphenoid (harlequin appearance of the orbit) (Fig.